H
Hidetoshi Kanai
Researcher at Kyushu University
Publications - 47
Citations - 1619
Hidetoshi Kanai is an academic researcher from Kyushu University. The author has contributed to research in topics: Hemodialysis & Kidney. The author has an hindex of 19, co-authored 45 publications receiving 1514 citations.
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Journal ArticleDOI
Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death.
Kazuhiko Tsuruya,Toshiharu Ninomiya,Masanori Tokumoto,Makoto Hirakawa,Kohsuke Masutani,Masatomo Taniguchi,Kyoichi Fukuda,Hidetoshi Kanai,Kenji Kishihara,Hideki Hirakata,Mitsuo Iida +10 more
TL;DR: Cisplatin-induced up-regulation of Fas, Fas ligand and TNF-alpha mRNAs in the kidney in vivo and in RTCs in vitro concludes that the Fas- and TNFR1-mediated apoptotic pathways are directly involved in the pathogenesis of cisplatin -induced RTC death process.
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Predominance of Th1 immune response in diffuse proliferative lupus nephritis.
Kohsuke Masutani,Mitsuteru Akahoshi,Kazuhiko Tsuruya,Masanori Tokumoto,Toshiharu Ninomiya,Tsutomu Kohsaka,Kyoichi Fukuda,Hidetoshi Kanai,Hitoshi Nakashima,Takeshi Otsuka,Hideki Hirakata +10 more
TL;DR: A predominance of Thl-type response in both peripheral and renal tissues of patients with DPLN is identified, suggesting that the peripheral blood Thl:Th2 ratio directly reflects the local histopathologic findings.
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Increased renal resistive index in atherosclerosis and diabetic nephropathy assessed by Doppler sonography
Yuko Ohta,Koji Fujii,Hisatomi Arima,Kiyoshi Matsumura,Takuya Tsuchihashi,Masanori Tokumoto,Kazuhiko Tsuruya,Hidetoshi Kanai,Masanori Iwase,Hideki Hirakata,Mitsuo Iida +10 more
TL;DR: It is suggested that the increased RI of the renal arteries is associated with the severity of systemic atherosclerosis, and the intrarenal vascular resistance differs depending on the underlying renal disease, and appears to increase to a greater extent in diabetic nephropathy.
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Reduced p21, p27 and vitamin D receptor in the nodular hyperplasia in patients with advanced secondary hyperparathyroidism
Masanori Tokumoto,Kazuhiko Tsuruya,Kyoichi Fukuda,Hidetoshi Kanai,Shoji Kuroki,Hideki Hirakata +5 more
TL;DR: The reduced expression of p21 and p27, in a VDR-dependent manner, is a major pathogenic factor for a nodular parathyroid gland growth.
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Antioxidant ameliorates cisplatin-induced renal tubular cell death through inhibition of death receptor-mediated pathways
Kazuhiko Tsuruya,Masanori Tokumoto,Toshiharu Ninomiya,Makoto Hirakawa,Kohsuke Masutani,Masatomo Taniguchi,Kyoichi Fukuda,Hidetoshi Kanai,Hideki Hirakata,Mitsuo Iida +9 more
TL;DR: The results suggest that antioxidants can ameliorate cisplatin-induced acute renal failure through inactivation of the death receptor-mediated apoptotic pathways.