H
Hillary A. Keenan
Researcher at Harvard University
Publications - 31
Citations - 1158
Hillary A. Keenan is an academic researcher from Harvard University. The author has contributed to research in topics: Type 1 diabetes & Diabetes mellitus. The author has an hindex of 16, co-authored 31 publications receiving 871 citations. Previous affiliations of Hillary A. Keenan include Genzyme & Joslin Diabetes Center.
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Journal ArticleDOI
Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction
Weier Qi,Hillary A. Keenan,Qian Li,Atsushi Ishikado,Aimo Kannt,Thorsten Sadowski,Mark A. Yorek,I-Hsien Wu,Samuel M. Lockhart,Lawrence J. Coppey,Anja Pfenninger,Chong Wee Liew,Guifen Qiang,Guifen Qiang,Alison Burkart,Stephanie M. Hastings,David M. Pober,Christopher Cahill,Monika A. Niewczas,William J. Israelsen,Liane J. Tinsley,Isaac E. Stillman,Peter S. Amenta,Edward P. Feener,Matthew G. Vander Heiden,Robert Stanton,George L. King +26 more
TL;DR: In this paper, a small-molecule pyruvate kinase M2 activator, TEPP-46, was used to prevent diabetic nephropathy.
Journal ArticleDOI
Protection From Retinopathy and Other Complications in Patients With Type 1 Diabetes of Extreme Duration: The Joslin 50-Year Medalist Study
Jennifer K. Sun,Hillary A. Keenan,Jerry D. Cavallerano,Bela F. Asztalos,Ernst J. Schaefer,David R. Sell,Christopher Strauch,Vincent M. Monnier,Alessandro Doria,Lloyd Paul Aiello,George L. King +10 more
TL;DR: The Medalist population is likely enriched for protective factors against complications, indicating a link between AGE formation or processing with development of diabetic vasculopathy.
Journal ArticleDOI
Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy
Daniel Gordin,Hetal Shah,Hetal Shah,Takanori Shinjo,Takanori Shinjo,Ronald St-Louis,Ronald St-Louis,Weier Qi,Weier Qi,Weier Qi,Kyoungmin Park,Kyoungmin Park,Samantha M. Paniagua,David Pober,David Pober,I-Hsien Wu,Vanessa Bahnam,Megan J. Brissett,Liane J. Tinsley,Jonathan M. Dreyfuss,Hui Pan,Yutong Dong,Monika A. Niewczas,Monika A. Niewczas,Peter S. Amenta,Peter S. Amenta,Thorsten Sadowski,Aimo Kannt,Hillary A. Keenan,Hillary A. Keenan,Hillary A. Keenan,George L. King,George L. King +32 more
TL;DR: The renal profile of elevated glycolytic enzymes and reduced toxic glucose metabolites is reflected in the circulation, supporting their use as biomarkers for endogenous renal protective factors in people with diabetes.
Journal ArticleDOI
Residual β cell function and monogenic variants in long-duration type 1 diabetes patients.
Marc Gregory Yu,Hillary A. Keenan,Hillary A. Keenan,Hetal Shah,Hetal Shah,Scott G. Frodsham,David M. Pober,Zhiheng He,Zhiheng He,Emily Wolfson,Stephanie D’Eon,Liane J. Tinsley,Susan Bonner-Weir,Susan Bonner-Weir,Marcus G. Pezzolesi,Marcus G. Pezzolesi,Marcus G. Pezzolesi,George L. King,George L. King +18 more
TL;DR: The Medalists were heterogeneous with respect to β cell function, and many with HLA+ diabetes risk alleles also had monogenic diabetes variants, indicating the importance of genetic testing for clinically diagnosed T1D.
Journal ArticleDOI
Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy.
Hisashi Yokomizo,Yasutaka Maeda,Kyoungmin Park,Allen C. Clermont,Sonia L. Hernandez,Ward Fickweiler,Qian Li,Chih-Hao Wang,Samantha M. Paniagua,Fabrício Simão,Atsushi Ishikado,Bei Sun,I-Hsien Wu,Sayaka Katagiri,David M. Pober,Liane J. Tinsley,Robert L. Avery,Edward P. Feener,Edward P. Feener,Timothy S. Kern,Hillary A. Keenan,Hillary A. Keenan,Lloyd Paul Aiello,Lloyd Paul Aiello,Jennifer K. Sun,Jennifer K. Sun,George L. King,George L. King +27 more
TL;DR: Elevated expression of photoreceptor-secreted RBP3 may have a role in protection against the progression of DR due to hyperglycemia by inhibiting glucose uptake via GLUT1 and decreasing the expression of inflammatory cytokines and VEGF.