H
Hiroaki Kajiyama
Researcher at Nagoya University
Publications - 388
Citations - 10270
Hiroaki Kajiyama is an academic researcher from Nagoya University. The author has contributed to research in topics: Medicine & Ovarian cancer. The author has an hindex of 49, co-authored 333 publications receiving 8535 citations.
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Journal ArticleDOI
Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells
Hiroaki Kajiyama,Kiyosumi Shibata,Mikio Terauchi,Mamoru Yamashita,Kazuhiko Ino,Akihiro Nawa,Fumitaka Kikkawa +6 more
TL;DR: There is a possible link between chronic paclitaxel-resistance and induction of the EMT in EOC cells, and therapeutic benefits such as the restoration of chemosensitivity or suppression of metastasis will be enabled by gaining further insight into the mechanisms underlying chemoresistance and EMT.
Journal ArticleDOI
Effect of Indirect Nonequilibrium Atmospheric Pressure Plasma on Anti-Proliferative Activity against Chronic Chemo-Resistant Ovarian Cancer Cells In Vitro and In Vivo
Fumi Utsumi,Hiroaki Kajiyama,Kae Nakamura,Hiromasa Tanaka,Masaaki Mizuno,Kenji Ishikawa,Hiroki Kondo,Hiroyuki Kano,Masaru Hori,Fumitaka Kikkawa +9 more
TL;DR: It is demonstrated that plasma-activated medium also had an anti-tumor effect on chemo-resistant cells in vitro and in vivo and may contribute to a better patient prognosis in the future.
Journal ArticleDOI
Plasma-Activated Medium Selectively Kills Glioblastoma Brain Tumor Cells by Down-Regulating a Survival Signaling Molecule, AKT Kinase
Hiromasa Tanaka,Masaaki Mizuno,Kenji Ishikawa,Kae Nakamura,Hiroaki Kajiyama,Hiroyuki Kano,Fumitaka Kikkawa,Masaru Hori +7 more
TL;DR: PAM downregulated the expression of AKT kinase, a marker molecule in a survival signal transduction pathway, which suggests that PAM may be a promising tool for therapy of glioblastoma brain tumors by downregulating the survival signals in cancers.
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Selective killing of ovarian cancer cells through induction of apoptosis by nonequilibrium atmospheric pressure plasma
Sachiko Iseki,Kae Nakamura,Moemi Hayashi,Hiromasa Tanaka,Hiroki Kondo,Hiroaki Kajiyama,Hiroyuki Kano,Fumitaka Kikkawa,Masaru Hori +8 more
TL;DR: Flow cytometry and western blot analysis showed that plasma treatment of ovarian cancer cells induced apoptosis, and nonequilibrium atmospheric pressure plasma could be a promising tool for therapy for ovarian cancers.
Journal ArticleDOI
Indoleamine 2,3-dioxygenase is a novel prognostic indicator for endometrial cancer.
Kazuhiko Ino,Norio Yoshida,Hiroaki Kajiyama,Kiyosumi Shibata,Eiko Yamamoto,Kumiko Kidokoro,Noriko Takahashi,Mikio Terauchi,Akihiro Nawa,Seiji Nomura,Tetsuro Nagasaka,Osamu Takikawa,Fumitaka Kikkawa +12 more
TL;DR: The results indicated that the high IDO expression was involved in the progression of endometrial cancer and correlated with the impaired clinical outcome, suggesting that IDO is a novel and reliable prognostic indicator for endometricrial cancer.