H
Hiroaki Kimura
Researcher at Jikei University School of Medicine
Publications - 16
Citations - 2124
Hiroaki Kimura is an academic researcher from Jikei University School of Medicine. The author has contributed to research in topics: Organic anion transporter 1 & Medicine. The author has an hindex of 6, co-authored 12 publications receiving 1956 citations. Previous affiliations of Hiroaki Kimura include Kyorin University.
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Journal ArticleDOI
Molecular identification of a renal urate anion exchanger that regulates blood urate levels.
Atsushi Enomoto,Hiroaki Kimura,Hiroaki Kimura,Arthit Chairoungdua,Yasuhiro Shigeta,Yasuhiro Shigeta,Promsuk Jutabha,Seok Ho Cha,Makoto Hosoyamada,Michio Takeda,Takashi Sekine,Takashi Igarashi,Hirotaka Matsuo,Hirotaka Matsuo,Yuichi Kikuchi,Takashi Oda,Kimiyoshi Ichida,Tatsuo Hosoya,Kaoru Shimokata,Toshimitsu Niwa,Yoshikatsu Kanai,Hitoshi Endou +21 more
TL;DR: This work identifies the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate–anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricOSuric agents (which affect excretion of uric acid).
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Human organic anion transporters and human organic cation transporters mediate renal antiviral transport.
Michio Takeda,Suparat Khamdang,Shinichi Narikawa,Hiroaki Kimura,Yasuna Kobayashi,Toshinori Yamamoto,Seok Ho Cha,Takashi Sekine,Hitoshi Endou +8 more
TL;DR: It is suggested that hOAT1 and hOCT1 mediate renal ACV and GCV transport, whereas h oAT1, hO AT2, h OAT3, and hoAT4 mediate kidneys AZT transport, and L-valyl ester appears to be important in differential substrate recognition between hOat1 and oAT3.
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Characterization of Methotrexate Transport and Its Drug Interactions with Human Organic Anion Transporters
Michio Takeda,Suparat Khamdang,Shinichi Narikawa,Hiroaki Kimura,Makoto Hosoyamada,Seok Ho Cha,Takashi Sekine,Hitoshi Endou +7 more
TL;DR: It was predicted that hOAT3 is the site of drug interactions between methotrexate and salicylate, phenylbutazone, indomethacin, and probenecid in vivo andKinetic analysis of inhibitory effects of these drugs on hOat3-mediated methot Rexate uptake revealed that these inhibitions were competitive.
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Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins
Hiroaki Kimura,Michio Takeda,Shinichi Narikawa,Atsushi Enomoto,Kimiyoshi Ichida,Hitoshi Endou +5 more
TL;DR: Considering the localization of these transporters, the results suggest that PGE(2) and PGF(2 alpha) transport in the basolateral membrane of the proximal tubule is mediated by multiple pathways including hOAT1,hOAT2, hOat3, and hOCT2, whereas that in the apical side is mediatedby hO AT4.
Journal ArticleDOI
Urate transport via human PAH transporter hOAT1 and its gene structure
Kimiyoshi Ichida,Makoto Hosoyamada,Hiroaki Kimura,Michio Takeda,Yasunori Utsunomiya,Tatsuo Hosoya,Hitoshi Endou +6 more
TL;DR: HOAT1 is not responsible for FJGN in the two sisters examined in this study, and the inhibition profiles of uricosuric and antiuricOSuric agents are defined.