Kaoru Shimokata

TL;DR: This work identifies the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate–anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricOSuric agents (which affect excretion of uric acid).

TL;DR: It is suggested that determination of the UGT1A1 genotypes might be clinically useful for predicting severe toxicity by irinotecan in cancer patients and warrants a prospective trial to corroborate the usefulness of gene diagnosis of UGT2A1 polymorphisms prior tb irinOTecan chemotherapy.

TL;DR: The results imply that the blaIMP gene cassettes have been dispersing into various gram-negative rods with the help of the newly identified integron element, which will be helpful for the early recognition of emerging bla IMP-positive clinical isolates which demonstrate consistent resistance to beta-lactams.

TL;DR: The presence of the p53 mutation was associated with a shortened survival in all patients, including those in early stages of the disease, and patients with 3p deletion tended to have a poorer prognosis, but not to a statistically significant extent.

TL;DR: A large registry study provides benchmark prognostic statistics for lung cancer, and the present tumor, node, metastasis staging system well characterizes the stage-specific prognoses.