Hiroaki Okuyama

TL;DR: It is reported that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitumor effects in mouse models of pancreatic neuroendocrine carcinoma and glioblastoma but concomitantly elicit tumor adaptation and progression to stages of greater malignancy, with heightened invasiveness and in some cases increased lymphatic and distant metastasis.

TL;DR: HIF-1 contributes to the epithelial-mesenchymal transition in VHL-null RCC by indirect repression of E-cadherin, a critical event in the pathogenesis of invasive and metastatic cancer.

TL;DR: It is demonstrated that aging and HIF-1 loss-of-function impair the expression of multiple angiogenic cytokines, mobilization ofAngiogenic cells, maintenance of tissue viability, and recovery of limb perfusion following femoral artery ligation and gene therapy can counteract the pathological effects of aging in a mouse model of limb ischemia.

TL;DR: An innovative culture method for primary colorectal cancer cells, based on the principle that cell–cell contact of cancer cells was maintained throughout the process, allowed evaluation of chemosensitivity and signal pathway activation in cancer cells from individual patients.

TL;DR: Results suggest that loss-of-function of a single tumor suppressor gene can up-regulate the expression of both a ligand and its receptor, which may establish an autocrine signaling pathway with important roles in the pathogenesis of hemangioblastoma and CC-RCC.