H
Hirokazu Okamoto
Researcher at Meijo University
Publications - 81
Citations - 2015
Hirokazu Okamoto is an academic researcher from Meijo University. The author has contributed to research in topics: Spray drying & Particle. The author has an hindex of 27, co-authored 81 publications receiving 1853 citations.
Papers
More filters
Journal ArticleDOI
Theophylline particle design using chitosan by the spray drying.
TL;DR: The results suggested that the spray-drying method is usefull to produce dry powders for inhalation, and the carbonyl group of theophylline and the amino group of chitosan formed a hydrogen bond.
Journal ArticleDOI
Pulmonary Gene Delivery by Chitosan–pDNA Complex Powder Prepared by a Supercritical Carbon Dioxide Process
TL;DR: Chitosan-plasmid DNA (pDNA) complex powders as a pulmonary gene delivery system were prepared with a supercritical carbon dioxide (CO(2)) process and their in vivo activity was evaluated.
Journal ArticleDOI
Application of supercritical fluid to preparation of powders of high-molecular weight drugs for inhalation.
Hirokazu Okamoto,Kazumi Danjo +1 more
TL;DR: The application of supercritical carbon dioxide to particle design has recently emerged as a promising way to produce powders of macromolecules such as proteins and genes and an insulin powder for inhalation was approved by authorities in Europe and the USA.
Journal ArticleDOI
Optimized pulmonary gene transfection in mice by spray-freeze dried powder inhalation.
TL;DR: Results suggest inhalable dry pDNA powders with chitosan prepared by SFD to be a suitable formulation for pulmonary gene therapy.
Journal ArticleDOI
Effect of additives on insulin absorption from intratracheally administered dry powders in rats.
TL;DR: Citric acid appears to be a safe and potent absorption enhancer for insulin in dry Powder using a spray drying technique to examine the effect of additives on insulin absorption.