Hiromi Sakashita

TL;DR: It is shown that mouse B16F10 melanoma cells constitutively express chemokine receptor CXCR3, and that its ligands CXCL9/Mig, CxCL10/IP-10, and CX CL11/I-TAC induce cellular responses in vitro, such as actin polymerization, migration, invasion, and cell survival.

TL;DR: It is shown that some human colon cancer cell lines express CXCR3 constitutively, and activation of CX CR3 with its ligands stimulates colon cancer metastasis preferentially to the draining lymph nodes with poorer prognosis.

TL;DR: These results suggest that, in metastatic liver cancers, glycolysis induced by HIF-1 is the predominant energy source under the hypoxic environment and, at least in some TAE-pretreated HCC cases, cancer cells obtain energy for growth by switching the metabolic profile to gly co-lysis through Hif-1.

TL;DR: The finding that after the reintroduction or the increase of IS fibrosis was improved supported the possibility that fibrosis in operationally tolerant patients was antigen dependent.

TL;DR: F focal C4d deposition was seen in various types of liver allograft injury and had little clinical impact on crossmatch-negative patients, but extensive C4D staining in crossmatch -positive patients may be associated with humoral rejection and poor graft survival.