H
Hiromichi Tanaka
Researcher at Showa University
Publications - 281
Citations - 4376
Hiromichi Tanaka is an academic researcher from Showa University. The author has contributed to research in topics: Derivative (chemistry) & Nucleoside. The author has an hindex of 32, co-authored 281 publications receiving 4282 citations. Previous affiliations of Hiromichi Tanaka include Tohoku Pharmaceutical University & Kagoshima University.
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Journal ArticleDOI
A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.
Tadashi Miyasaka,Hiromichi Tanaka,Masanori Baba,Hiroyuki Hayakawa,Richard T. Walker,Jan Balzarini,Erik De Clercq +6 more
TL;DR: La synthese du compose du titre est donnee, cet analogue de nucleoside possede une activite anti-HIV-1
Journal ArticleDOI
Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.
Masanori Baba,Hiromichi Tanaka,E. De Clercq,Rudi Pauwels,Jan Balzarini,Dominique Schols,Hideki Nakashima,Carlo Federico Perno,Richard T. Walker,Tadashi Miyasaka +9 more
TL;DR: A novel 6-substituted acyclouridine derivative, HEPT, has proved to be a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) in vitro.
Journal ArticleDOI
Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents
Hiromichi Tanaka,H Takashima,M Ubasawa,Kouichi Sekiya,Issei Nitta,Masanori Baba,Shiro Shigeta,R. T. Walker,E. De Clercq,T. Miyasaka +9 more
TL;DR: The effect of substitution in the acyclic structure of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)-thymine (HEPT) on anti-HIV-1 activity was investigated by synthesizing a series of deoxy analogs and related compounds.
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A new class of HIV-1-specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).
Hiromichi Tanaka,Masanori Baba,Hiroyuki Hayakawa,Takashi Sakamaki,Tadashi Miyasaka,Masaru Ubasawa,Hideaki Takashima,Kouichi Sekiya,Issei Nitta,Shiro Shigeta,Richard T. Walker,Jan Balzarini,Erik De Clercq +12 more
TL;DR: A series of novel acyclouridine derivatives substituted at both the C-5 and C-6 positions were synthesized for the purpose of improving the activity of a recently reported HIV-1-specific lead, 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).
Journal ArticleDOI
Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity.
Hiromichi Tanaka,H Takashima,M Ubasawa,Kouichi Sekiya,Issei Nitta,Masanori Baba,Shiro Shigeta,R. T. Walker,E. De Clercq,T. Miyasaka +9 more
TL;DR: Substitution at the meta position of the C-6-(phenylthio) ring by the methyl group improved the original anti-HIV-1 activity of HEPT, and introduction of two m-methyl groups to the phenylthIO ring further potentiated the activity.