H
Hiroshi Fujii
Researcher at Tohoku University
Publications - 182
Citations - 3180
Hiroshi Fujii is an academic researcher from Tohoku University. The author has contributed to research in topics: Systemic lupus erythematosus & Antibody. The author has an hindex of 28, co-authored 182 publications receiving 2767 citations. Previous affiliations of Hiroshi Fujii include University of Tokyo & Nippon Telegraph and Telephone.
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Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells
TL;DR: T cells from RA patients are hypoglycolytic due to insufficient induction of the glyCOlytic activator PFKFB3, resulting in impaired autophagy and reduced ROS production.
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Telomerase insufficiency in rheumatoid arthritis
TL;DR: Restoring defective telomerase activity emerges as a therapeutic target in resetting immune abnormalities in RA and results in excessive T cell loss, undermining homeostatic control of the naive T cell compartment and setting the stage for lymphopenia-induced T cell repertoire remodeling.
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Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis.
TL;DR: It is shown that ATM deficiency in RA disrupts DNA repair and renders T cells sensitive to apoptosis, and Restoration of DNA repair mechanisms emerges as an important therapeutic target in RA.
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Telomeres, immune aging and autoimmunity
TL;DR: Telomere length is important in constraining the replicative potential of cells; cellular systems that are dependent on cell replenishment for renewal or on cell proliferation for functionality are highly sensitive to telomeric erosion.
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Rejuvenating the immune system in rheumatoid arthritis
TL;DR: Therapeutic attempts to reset the immune systems of patients with RA and prevent premature immunosenescence should include restoration of DNA repair capability.