Ines Colmegna

TL;DR: In this paper, plasmacytoid dendritic cells (pDCs) that specialize in sensing bacterial and viral products can regulate effector functions of plaque-residing T cells and thus connect host infection and plaque instability.

TL;DR: Current evidence supports the concept that reactive arthritis (ReA) is an immune-mediated synovitis resulting from slow bacterial infections and showing intra-articular persistence of viable, nonculturable bacteria and/or immunogenetic bacterial antigens synthesized by metabolically active bacteria residing in the joint and/ or elsewhere in the body.

TL;DR: Restoring defective telomerase activity emerges as a therapeutic target in resetting immune abnormalities in RA and results in excessive T cell loss, undermining homeostatic control of the naive T cell compartment and setting the stage for lymphopenia-induced T cell repertoire remodeling.

TL;DR: It is shown that ATM deficiency in RA disrupts DNA repair and renders T cells sensitive to apoptosis, and Restoration of DNA repair mechanisms emerges as an important therapeutic target in RA.

TL;DR: An extensive simulation study built on cell-separated DNA methylation profiles from Illumina Infinium 450K methylation data is presented to compare the performance of eight methods including the most commonly used approaches and recommends surrogate variable analysis for cell-type mixture adjustment.