H
Hiroshi Hatanaka
Publications - 65
Citations - 3695
Hiroshi Hatanaka is an academic researcher. The author has contributed to research in topics: Streptomyces tsukubaensis & Streptomyces. The author has an hindex of 14, co-authored 65 publications receiving 3578 citations.
Papers
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Journal ArticleDOI
FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.
Toru Kino,Hiroshi Hatanaka,Susumu Miyata,Noriaki Inamura,Michihisa Nishiyama,Toshimi Yajima,Toshio Goto,Masakuni Okuhara,Masanobu Kohsaka,Hatsuo Aoki,Takenori Ochiai +10 more
TL;DR: FFK-506, a novel immunosuppressant, has been isolated from the fermentation broth of Streptomyces tsukubaenis No. 9993 as colorless prism and the molecular formula was determined as C44H69NO12.H2O.
Journal ArticleDOI
FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.
Toru Kino,Hiroshi Hatanaka,Michisane Hashimoto,Michihisa Nishiyama,Toshio Goto,Masakuni Okuhara,Masanobu Kohsaka,Hatsuo Aoki,Hiroshi Imanaka +8 more
TL;DR: FFK-506, a novel immunosuppressant, has been isolated from the fermentation broth of Streptomyces tsukubaenis No. 9993 as colorless prism and the molecular formula was determined as C44H69NO12.H2O.
Journal ArticleDOI
Structure of FK506, a novel immunosuppressant isolated from Streptomyces
Hirokazu Tanaka,Akio Kuroda,Hiroshi Marusawa,Hiroshi Hatanaka,Toru Kino,Toshio Goto,Masashi Hashimoto,Toru Taga +7 more
Patent
Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
TL;DR: In this article, tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation and autoimmune diseases, infectious diseases, and the like can be represented by the following formula: to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
Journal ArticleDOI
FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics.
Hiroshi Hatanaka,Tohru Kino,Susumu Miyata,Noriaki Inamura,Akio Kuroda,Toshio Goto,Hirokazu Tanaka,Masakuni Okuhara +7 more
TL;DR: Novel neutral macrolide immunosuppressants isolated from the cultured broth of Streptomyces hygroscopicus subsp.