H
Hiroshi Kunugi
Researcher at Teikyo University
Publications - 486
Citations - 18691
Hiroshi Kunugi is an academic researcher from Teikyo University. The author has contributed to research in topics: Bipolar disorder & Schizophrenia. The author has an hindex of 66, co-authored 461 publications receiving 15947 citations. Previous affiliations of Hiroshi Kunugi include University of Cambridge & Tokyo Medical and Dental University.
Papers
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BDNF function and intracellular signaling in neurons.
TL;DR: A broad overview of the current knowledge concerning BDNF action and associated intracellular signaling as it relates to neuronal protection, synaptic function, and morphological change is presented.
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Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex
Shuichi Chiba,Tadahiro Numakawa,Midori Ninomiya,Misty Richards,Chisato Wakabayashi,Hiroshi Kunugi +5 more
TL;DR: The results suggest that reduced GR expression and altered BDNF function may be involved in chronic stress-induced anxiety--and depression-like behaviors.
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Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder
Emiko Aizawa,Hirokazu Tsuji,Takashi Asahara,Takuya Takahashi,Toshiya Teraishi,Sumiko Yoshida,Miho Ota,Norie Koga,Kotaro Hattori,Hiroshi Kunugi +9 more
TL;DR: Evidence is provided for the first time that individuals with lower Bifidobacterium and/or Lactobacillus counts are more common in patients with MDD compared to controls, and an association between the bacterial counts and Irritable bowel syndrome is observed.
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Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia
Tadahiro Numakawa,Yuki Yagasaki,Tetsuya Ishimoto,Takeya Okada,Tatsuyo Suzuki,Nakao Iwata,Norio Ozaki,Takahisa Taguchi,M Tatsumi,Kunitoshi Kamijima,Richard E. Straub,Daniel R. Weinberger,Hiroshi Kunugi,Ryota Hashimoto +13 more
TL;DR: In this paper, the authors found a nominally significant association with schizophrenia for four single nucleotide polymorphisms and stronger evidence for association in a multi-marker haplotype analysis (P = 0.00028).
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Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder
Hiroshi Kunugi,Mineko Hattori,Tadafumi Kato,M Tatsumi,Toshiyuki Sakai,T. Sasaki,Tetsuya Hirose,Shinichiro Nanko +7 more
TL;DR: The results suggest that the VNTR itself or another unknown functional polymorphism which would be in linkage disequilibrium to the VnTR has an effect on susceptibility to bipolar disorder.