Hiroshi Maruyama

TL;DR: It is demonstrated that increasing levels of piroxicam in the diet, when fed 1 or 13 wk after carcinogen insult, inhibit colon tumor incidence in a dose-dependent manner and colon tumor multiplicity was slightly but significantly inhibited in animals fed the diets containing 25 to 150 ppm piroXicam.

TL;DR: The results of this study indicate that fish oils rich in highly polyunsaturated n-3 fatty acids do not enhance large bowel carcinogenesis and that the fatty acid composition of the dietary fat is one of the determining factors in large bowel cancerogenesis.

TL;DR: The occurrence of vitiligo during nivolumab treatment may be correlated with favorable clinical outcome and prolonged progression‐free and overall survival in advanced melanoma patients.

TL;DR: The results from Japanese patients with LAM confirmed the current concept of pathogenesis of LAM: TSC-LAM has a germline mutation but sporadic LAM does not; sporadic L AM is a TSC2 disease with two somatic mutations; and a variety of TSC mutations causes LAM.

TL;DR: Liposome-encapsulated human recombinant superoxide dismutase (LSOD) protected male rats that were pretreated with 3-methylcholanthrene from the liver necrosis produced by acetaminophen by contrast, SOD-free liposomes, free SOD, or heat-denatured LSOD had no protective effect.