H
Hiroshi Masutani
Researcher at Prevention Institute
Publications - 151
Citations - 10187
Hiroshi Masutani is an academic researcher from Prevention Institute. The author has contributed to research in topics: Thioredoxin & Oxidative stress. The author has an hindex of 55, co-authored 151 publications receiving 9703 citations. Previous affiliations of Hiroshi Masutani include Tenri Health Care University & Pasteur Institute.
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Journal ArticleDOI
Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated Protein 1 as a Negative Regulator of Thioredoxin Function and Expression
Akira Nishiyama,Minoru Matsui,Satoshi Iwata,Kiichi Hirota,Hiroshi Masutani,Hajime Nakamura,Yasushi Takagi,Hiroshi Sono,Yasuhiro Gon,Junji Yodoi +9 more
TL;DR: The results suggested that TBP-2/VDUP1 serves as a negative regulator of the biological function and expression of TRX, an important redox regulatory mechanism in cellular processes, including differentiation of myeloid and macrophage lineages.
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Redox Control of Cell Death
TL;DR: Mitochondria-specific thioredoxin (Trx-2) and Trx peroxidases (peroxiredoxins) are suggested to regulate cytochrome c release from mitochondria, which is a critical early step in the apoptotis-signaling pathway.
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Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation
Masaya Ueno,Hiroshi Masutani,Roberto J. Arai,Akira Yamauchi,Kiichi Hirota,Toshiyuki Sakai,Takashi Inamoto,Yoshio Yamaoka,Junji Yodoi,Toshio Nikaido +9 more
TL;DR: TRX-dependent redox regulation of p53 activity indicates coupling of the oxidative stress response and p53-dependent repair mechanism.
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Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation
Hisae Kadowaki,Hisae Kadowaki,Hideki Nishitoh,Hideki Nishitoh,Fumihiko Urano,Chiharu Sadamitsu,Atsushi Matsuzawa,Kohsuke Takeda,Hiroshi Masutani,Junji Yodoi,Y. Urano,Tetsuo Nagano,Hidenori Ichijo +12 more
TL;DR: The results indicate that ROS-mediated ASK1 activation is a key mechanism for Aβ-induced neurotoxicity, which plays a central role in Alzheimer's disease.
Journal ArticleDOI
Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis.
Toru Tanaka,Fumihito Hosoi,Yuko Yamaguchi-Iwai,Hajime Nakamura,Hiroshi Masutani,Hiroshi Masutani,Shugo Ueda,Akira Nishiyama,Shunichi Takeda,Hiromi Wada,Giannis Spyrou,Junji Yodoi,Junji Yodoi +12 more
TL;DR: It is shown that TRX‐2 is an essential gene and that Trx‐2‐deficient cells undergo apoptosis upon repression of the TRX•2 transgene, showing an accumulation of intracellular reactive oxygen species (ROS).