Hiroshi Nakano

TL;DR: The present study suggests that SI resulted in a poorer liver functional reserve and in a higher complication rate after major hepatectomy, and female patients who received 6 cycles or more of OBC, or presenting with abnormal preoperative aspartate aminotransferase and ICG-R15 values should be carefully selected before deciding to undertake a major hepATEctomy.

TL;DR: This surgical procedure is followed by a promising survival rate and can be recommended in order to obtain a margin-negative resection; however, candidates for SM-PVR should be carefully selected.

TL;DR: It is suggested that NAC enhances the concentrations of cysteine within hepatocytes, providing a substrate for glutathione synthesis during reperfusion, and indicates that the protective effect of NAC on cold ischemia-reperfusion liver injury persisted when animals were pretreated with buthionine sulfoximine (BSO), a specific inhibitor of glutathiona synthesis.

TL;DR: Preoperative patient selection and appropriate surgical technique, sometimes combined with preoperative portal embolization and local tumor destruction (radiofrequency and cryotherapy), may increase the resectability and the safety of the procedure.

TL;DR: Monoclonal cell expansion is seen in a considerable number of regenerative nodules in cirrhotic liver and indicates that certain genetic changes, which are required for hepatocarcinogenesis, have already occurred in these nodules.