Journal ArticleDOI
Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy.
Hiroshi Nakano,Elie Oussoultzoglou,Edoardo Rosso,Selenia Casnedi,Marie-Pierre Chenard-Neu,Patrick Dufour,Philippe Bachellier,Daniel Jaeck +7 more
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TLDR
The present study suggests that SI resulted in a poorer liver functional reserve and in a higher complication rate after major hepatectomy, and female patients who received 6 cycles or more of OBC, or presenting with abnormal preoperative aspartate aminotransferase and ICG-R15 values should be carefully selected before deciding to undertake a major hepATEctomy.Abstract:
Objective:To investigate whether sinusoidal injury (SI) was associated with a worse outcome after hepatectomy in patients with colorectal liver metastases (CRLM).Background:Correlation between SI and oxaliplatin-based chemotherapy (OBC) was recently shown in patients with CRLM. However, it has yet tread more
Citations
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The Clavien-Dindo classification of surgical complications: five-year experience.
Pierre A. Clavien,Jeffrey Barkun,Michelle L. de Oliveira,Jean Nicolas Vauthey,Daniel Dindo,Richard D. Schulick,Eduardo de Santibañes,Juan Pekolj,Ksenija Slankamenac,Claudio Bassi,Rolf Graf,René Vonlanthen,Robert Padbury,John L. Cameron,Masatoshi Makuuchi +14 more
TL;DR: This 5-year evaluation provides strong evidence that the classification of complications is valid and applicable worldwide in many fields of surgery, and subjective, inaccurate, or confusing terms such as “minor or major” should be removed from the surgical literature.
Journal ArticleDOI
Posthepatectomy liver failure: A definition and grading by the International Study Group of Liver Surgery (ISGLS)
Nuh N. Rahbari,O. James Garden,Robert Padbury,Mark Brooke-Smith,Michael Crawford,René Adam,Moritz Koch,Masatoshi Makuuchi,Ronald P. DeMatteo,Christopher Christophi,Simon W. Banting,Val Usatoff,Masato Nagino,Guy J. Maddern,Thomas J. Hugh,Jean Nicolas Vauthey,Paul D. Greig,Myrddin Rees,Yukihiro Yokoyama,Sheung Tat Fan,Yuji Nimura,Joan Figueras,Lorenzo Capussotti,Markus W. Büchler,Jürgen Weitz +24 more
TL;DR: A definition and grading of severity of posthepatectomy liver failure is proposed, which can be used in future studies to allow objective and accurate comparisons of operative interventions in the field of hepatic surgery.
Journal ArticleDOI
ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making
H.-J. Schmoll,E. Van Cutsem,Alexander Stein,Vincenzo Valentini,Bengt Glimelius,Bengt Glimelius,Karin Haustermans,Bernard Nordlinger,C.J.H. van de Velde,Judith Balmaña,Jaroslaw Regula,Iris D. Nagtegaal,Regina G. H. Beets-Tan,D Arnold,Fortunato Ciardiello,Paulo M. Hoff,David J. Kerr,C.-H. Köhne,Roberto Labianca,Timothy J. Price,Werner Scheithauer,Alberto Sobrero,Josep Tabernero,Dan Aderka,S Barroso,György Bodoky,J.-Y. Douillard,H El Ghazaly,Jorge Gallardo,August Garin,Rob Glynne-Jones,Karin Jordan,A Meshcheryakov,D Papamichail,Per Pfeiffer,Ioannis Souglakos,Serdar Turhal,Andrés Cervantes +37 more
TL;DR: This ESMO guideline is recommended to be used as the basis for treatment and management decisions, delivering a clear proposal for diagnostic and treatment measures in each stage of rectal and colon cancer and the individual clinical situations.
Journal ArticleDOI
Pathologic Response to Preoperative Chemotherapy: A New Outcome End Point After Resection of Hepatic Colorectal Metastases
Dan G. Blazer,Yoji Kishi,Dipen M. Maru,Scott Kopetz,Yun Shin Chun,Michael J. Overman,David R. Fogelman,Cathy Eng,David Z. Chang,Huamin Wang,Daria Zorzi,Dario Ribero,Lee M. Ellis,Katrina Y. Glover,Robert A. Wolff,Steven A. Curley,Eddie K. Abdalla,Jean Nicolas Vauthey +17 more
TL;DR: Evaluated patients who underwent preoperative irinotecan- or oxaliplatin-based chemotherapy, followed by resection of colorectal liver metastases found that degree of pathologic response represents a new outcome end point for prognosis after resections of CLM.
EASL Clinical Practice Guidelines: Vascular diseases of the liver q
TL;DR: These guidelines will not cover all possible vascular disorders of the liver but are mainly based on the subjects discussed during the monothematic conference; Budd-Chiari syndrome, non-cirrhotic portal vein thrombosis, idiopathic portal hypertension, sinusoidal obstruction syndrome, hepatic vascular malformations in hereditary haemorrhagic telangiectasia and portal vein blood clotting problems in cirrhosis.
References
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Journal ArticleDOI
Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.
TL;DR: The new complication classification appears reliable and may represent a compelling tool for quality assessment in surgery in all parts of the world.
Journal ArticleDOI
Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer
A. de Gramont,A. Figer,M. Seymour,M. Homerin,A. Hmissi,J. Cassidy,Corrado Boni,H. Cortes-Funes,Andrés Cervantes,Gilles Freyer,Demetris Papamichael,N. Le Bail,C. Louvet,D. Hendler,F. de Braud,C. Wilson,Francois Morvan,Andrea Bonetti +17 more
TL;DR: The LV5FU2-oxaliplatin combination seems beneficial as first-line therapy in advanced colorectal cancer, demonstrating a prolonged progression-free survival with acceptable tolerability and maintenance of QoL.
Journal ArticleDOI
Clinical Score for Predicting Recurrence After Hepatic Resection for Metastatic Colorectal Cancer: Analysis of 1001 Consecutive Cases
TL;DR: There is a need for clearly defined and widely applicable clinical criteria for the selection of patients who may benefit from hepatic resection for metastatic colorectal cancer and studies of preoperative staging techniques or of adjuvant therapies should consider using such a score for stratification of patients.
Journal ArticleDOI
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial
Jean-Yves Douillard,David Cunningham,Arnaud Roth,M. Navarro,Roger D James,P. Karasek,P. Jandik,Timothy Iveson,Joseph C. Carmichael,M. Alakl,G. Gruia,Lucile Awad,Philippe Rougier +12 more
TL;DR: Irinotecan combined with fluorouracil and calcium folinate was well-tolerated and increased response rate, time to progression, and survival, with a later deterioration in quality of life.
Journal ArticleDOI
Recurrence and Outcomes Following Hepatic Resection, Radiofrequency Ablation, and Combined Resection/Ablation for Colorectal Liver Metastases
Eddie K. Abdalla,Jean Nicolas Vauthey,Lee M. Ellis,Vickie Ellis,Raphael E. Pollock,Kristine Broglio,Kenneth R. Hess,Steven A. Curley +7 more
TL;DR: Hepatic resection is the treatment of choice for colorectal liver metastases and RFA alone or in combination with resection for unresectable patients does not provide survival comparable to resection, and provides survival only slightly superior to nonsurgical treatment.
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