Showing papers in "Hepatology in 1995"

TL;DR: DNA fragmentation is common to different kinds of cell death; its detection in situ should not be considered a specific marker of apoptosis.

TL;DR: In the absence of preexisting fibrosis or steatohepatitis, fatty liver of nonalcohol‐induced origin is an extremely benign condition.

TL;DR: To establish a formula for calculating the standard LV in the pediatric and adult populations for liver transplantation, whole LVs were measured in 96 patients with normal liver whose disease conditions did not seem to affect body weight (BW) or LV.

TL;DR: The discovery and characterization of the main causative agent of non-A, non-B hepatitis (NANBH) represent a major success in the application of cloning techniques in the identification of new infectious agents.

TL;DR: There are no specific therapies for FHF, however, liver transplantation is recommended for situations in which spontaneous recovery appears unlikely and a suitable liver graft is available for transplantation.

TL;DR: Pretreatment serum HCV RNA levels and HCV genotype are the main and independent factors associated with sustained response to IFN therapy and these factors are significantly different in the three response groups.

TL;DR: It is demonstrated not only that patients with PSC and UC have a significantly higher risk of developing colorectal neoplasia compared with patients having UC only, but also that Patients with P SC and UC having coloreCTal neoperasia are more prone to develop cholangiocarcinoma.

TL;DR: T-cell-dependent concanavalin A-induced apoptotic liver injury in mice is related to immunological and cytokinemediated disorders and possibly to autoreactive hepatic processes.

TL;DR: The incidence of hepatocellular carcinoma (HCC) was prospectively studied in 251 chronic hepatitis patients, and was compared between the 127 cases of hepatitis B and 124 cases of liver disease, finding that the incidence of HCC was significantly higher in chronic hepatitis C than in hepatitis B.

TL;DR: Observations suggest that thrombosis of medium and large PVs and HVs is a frequent occurrence in cirrhosis, and that these events are important in causing progression of Cirrhosis.

TL;DR: Evidence of hepatic injury in regular users of alcohol, especially chronic alcoholics, who take APAP with therapeutic intent is provided, and the syndrome of liver injury is distinctive, marked by uniquely elevated levels of AST, and poses a significant threat.

TL;DR: High proportion of patients with HBsAg‐positive compensated cirrhosis do not experience worsening of their condition for several years, but once decompensation occurs life expectancy is poor, and European, white patients with compensated Cirrhosis type B are at consistent risk for HCC.

TL;DR: It is concluded that markers of autoimmunity occur with high and equal frequency in men and women with chronic hepatitis C and should not preclude therapy with IFN, which often improves hepatitis and features of autoimmune disease in patients with both.

TL;DR: The data suggest that the incidence and prevalence of hepatocellular carcinoma in hepatitis B carriers in the area, an urban North American setting, are as high as in countries where hepatitis B is endemic.

TL;DR: Induction immunotherapy, by reducing the rate of early rejection, may delay the clinical recurrence of hepatitis C and is associated with a higher incidence and earlier presentation of recurrent hepatitis C.

TL;DR: HCC was found at early stage among the patients receiving periodic medical checkups beforehand, and the prognosis of these HCC patients was significantly better than those who did not receive checkups, which means periodical screening naturally improves prognosis.

TL;DR: The hepatic steatosis associated with parenteral nutrition can be ameliorated, and possibly prevented, with choline supplementation, and choline may be an essential nutrient for patients who require long‐term parenTERal nutrition.

TL;DR: The identification of Stat3 as an early factor in liver regeneration provides clues to the activation of signal transduction pathways in the remnant liver within the first minutes to several hours after partial hepatectomy.

TL;DR: In women, F NH is now much more often detected than HA, and using enhanced MRI, a preoperative diagnosis of FNH is possible in 70% of the cases, avoiding unnecessary surgery.

TL;DR: Data indicate that the protection afforded the animals by pretreatment with macrophage modulators was not due to suppression of the formation of NAPQI and hence support the hypothesis that macrophages may contribute directly to acetaminophen hepatotoxicity by an independent mechanism.

TL;DR: The data suggest that diclofenac‐related liver injury is particularly likely to involve osteoarthritic females, presenting with jaundice 1 to 6 months after starting dicL ofenac, with injury that is predominantly hepatocellular and presumably caused by metabolic idiosyncrasy.

TL;DR: The reported series on seroprevalence of HCV indicate that HCV is found in more than 10% of HBV‐ or HDV‐infected patients worldwide, and clearly suggest the necessity of monitoring patients with HBV orHDV infections.

TL;DR: In this article, the authors studied the specificity of the TUNEL-based DNA fragment detection in well-defined models of apoptosis and necrosis as well as in postmortem autolysis in rat liver.

TL;DR: The results suggest the frequent integration of the HBV genome and the accumulation of X‐related RNAs in HCCs developing in HBsAg‐negative patients.

TL;DR: Subsequent investigation into defining the cellular regulatory mechanisms and biochemical processes involved will be fertile ground for future research that may ultimately lead to novel therapeutic approaches for autoimmune diseases, malignancies, and viral disease.

TL;DR: Virological features of HCV infection might be associated with different clinical manifestations, suggesting a potential prognostic significance on disease outcome, and isolated genotype II was progressively more represented in advanced liver disease, such as cirrhosis and HCC.

TL;DR: It is concluded that cytokines strongly repress the inducibility of CYP1As and CYP3A4 genes at a transcriptional or a posttranscriptional level, but affect neither the rate of translation of CyP mRNAs nor the rateof degradation of the CYP proteins in these cultures.

TL;DR: It is concluded that right portal vein embolization can produce a compensatory hypertrophy of the left lobe within 11 days without seriously affecting hepatic function, however, in diabetic patients, a longer interval betweenembolization and operation may be needed to achieve sufficient hypertrophies of theleft lobe.