H
Hiroyuki Moriyama
Researcher at Kindai University
Publications - 33
Citations - 1010
Hiroyuki Moriyama is an academic researcher from Kindai University. The author has contributed to research in topics: Stem cell & Cellular differentiation. The author has an hindex of 17, co-authored 29 publications receiving 856 citations. Previous affiliations of Hiroyuki Moriyama include Kyoto University & Harvard University.
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Journal ArticleDOI
Multiple roles of Notch signaling in the regulation of epidermal development.
Mariko Moriyama,André-Dante Durham,Hiroyuki Moriyama,Kiyotaka Hasegawa,Shin-Ichi Nishikawa,Freddy Radtke,Masatake Osawa +6 more
TL;DR: It is shown that Notch signaling determines spinous cell fate and induces terminal differentiation by a mechanism independent of Hes1, but Hes1 is required for maintenance of the immature state of spinous cells.
Journal ArticleDOI
Various types of HIV mixed infections in Cameroon.
Jun Takehisa,Leopold Zekeng,Eiji Ido,Innocent Mboudjeka,Hiroyuki Moriyama,Tomoyuki Miura,Masahiro Yamashita,Lutz G. Gürtler,Masanori Hayami,Lazare Kaptue +9 more
TL;DR: The mixed infection is particularly significant where there is a greater variety of HIV-1 subtypes circulating, since it results in new genetic diversity generated by intersubtype recombination.
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Hypoxia Increases Gefitinib-Resistant Lung Cancer Stem Cells through the Activation of Insulin-Like Growth Factor 1 Receptor
Akiko Murakami,Fumiyuki Takahashi,Fariz Nurwidya,Isao Kobayashi,Kunihiko Minakata,Muneaki Hashimoto,Takeshi Nara,Motoyasu Kato,Ken Tajima,Naoko Shimada,Shin-ichiro Iwakami,Mariko Moriyama,Hiroyuki Moriyama,Fumiaki Koizumi,Kazuhisa Takahashi +14 more
TL;DR: It is suggested that hypoxia increased the population of lung CSCs resistant to gefitinib in EGFR mutation-positive NSCLC by activating IGF1R, and targeting the IGF1 R pathway may be a promising strategy for overcoming gefitsinib resistance.
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Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors.
Kunihiko Minakata,Fumiyuki Takahashi,Takeshi Nara,Muneaki Hashimoto,Ken Tajima,Akiko Murakami,Fariz Nurwidya,Suzu Yae,Fumiaki Koizumi,Hiroyuki Moriyama,Kuniaki Seyama,Kazuto Nishio,Kazuhisa Takahashi +12 more
TL;DR: Results indicate that hypoxia causes gefitinib resistance in EGFR‐mutant NSCLC through the activation of wild‐type EGFR mediated by the upregulation of TGFα.
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Beneficial Effects of the Genus Aloe on Wound Healing, Cell Proliferation, and Differentiation of Epidermal Keratinocytes.
Mariko Moriyama,Hiroyuki Moriyama,Junki Uda,Hirokazu Kubo,Yuka Nakajima,Arisa Goto,Junji Akaki,Ikuyo Yoshida,Nobuya Matsuoka,Takao Hayakawa +9 more
TL;DR: Aloe vera gel (AVG) and Cape aloe extract (CAE) significantly improved wound healing in human primary epidermal keratinocytes (HPEKs) and a human skin equivalent model and gene expression of differentiation markers in HPEKs was increased, suggesting roles for AVG and CAE in the improvement of keratinocyte function.