H
Hiroyuki Nishimura
Researcher at Toin University of Yokohama
Publications - 132
Citations - 5518
Hiroyuki Nishimura is an academic researcher from Toin University of Yokohama. The author has contributed to research in topics: T cell & Polyethylene glycol. The author has an hindex of 33, co-authored 124 publications receiving 5076 citations. Previous affiliations of Hiroyuki Nishimura include University of Tokyo.
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Journal ArticleDOI
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
Yasutoshi Agata,Akemi Kawasaki,Hiroyuki Nishimura,Yasumasa Ishida,Takeshi Tsubata,Hideo Yagita,Tasuku Honjo +6 more
TL;DR: The results suggest that the expression of thePD-1 antigen is tightly regulated and induced by signal transduction through the antigen receptor and do not exclude the possibility that the PD- 1 antigen may play a role in clonal selection of lymphocytes although PD-1 expression is not required for the common pathway of apoptosis.
Journal ArticleDOI
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
TL;DR: Results show that PD-1 can inhibit B CR signaling by recruiting SHP-2 to its phosphotyrosine and dephosphorylating key signal transducers of BCR signaling.
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Seven-color Fluorescence Imaging of Tissue Samples Based on Fourier Spectroscopy and Singular Value Decomposition
Hiromichi Tsurui,Hiroyuki Nishimura,Susumu Hattori,Sachiko Hirose,Ko Okumura,Toshikazu Shirai +5 more
TL;DR: Seven-color analyses of immunofluorescence-stained tissue samples were accomplished using Fourier spectroscopy-based hyperspectral imaging and singular value decomposition of the matrices consisting of dye spectra to resolve their relative contributions to the fluorescent signal.
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Biomedical and biotechnological applications of PEG- and PM-modified proteins.
Yuji Inada,Makoto Furukawa,Hideyuji Sasaki,Yoh Kodera,Misao Hiroto,Hiroyuki Nishimura,Ayako Matsushima +6 more
TL;DR: Modification with PEG can increase the solubility and activity of enzymes in organic solvents, thus extending their potential for application in organic syntheses and biotransformation processes.
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Cell cycle arrest and apoptosis of leukemia cells induced by L-asparaginase.
Tomoo Ueno,K Ohtawa,Kenichi Mitsui,Yoh Kodera,Misao Hiroto,Ayako Matsushima,Yuji Inada,Hiroyuki Nishimura +7 more
TL;DR: Apoptotic cell death of murine leukemia cells induced by E. coli L-asparaginase is an event that is associated with the cell cycle arrest in G1 phase.