H
Hisashi Shirohara
Researcher at University of Occupational and Environmental Health Japan
Publications - 12
Citations - 326
Hisashi Shirohara is an academic researcher from University of Occupational and Environmental Health Japan. The author has contributed to research in topics: Cholecystokinin & Pancreatitis. The author has an hindex of 9, co-authored 12 publications receiving 317 citations.
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High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidemia in normal adult male Wistar rat
TL;DR: Feeding of high-fat hypercaloric diet makes normal Wistar male adult rat obese associated with hyperlipidemia, hyperinsulinemia, and glucose intolerance, indicating the presence of insulin resistance.
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Defects of cholecystokinin (CCK)-A receptor gene expression and CCK-A receptor-mediated biological functions in Otsuka Long-Evans Tokushima Fatty (OLETF) rats
Hayato Nakamura,Yasuyuki Kihara,Mitsuo Tashiro,Kenji Kanagawa,Hisashi Shirohara,Mitsuyoshi Yamamoto,Hiroyuki Yoshikawa,Ken-Ichiro Fukumitsu,Yoshihide Hirohata,Makoto Otsuki +9 more
TL;DR: It is confirmed that OLETF rats have CCK-A receptor gene anomalies and demonstrated deficient CCK -A receptor-mediated biological function in the pancreas, stomach, and brain.
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Role of endogenous cholecystokinin and cholecystokinin-A receptors in the development of acute pancreatitis in rats.
Issei Tachibana,Hisashi Shirohara,László Czakó,Toshiharu Akiyama,Shigekazu Nakano,Nobuaki Watanabe,Yoshihide Hirohata,Makoto Otsuki +7 more
TL;DR: Evaluating the involvement of endogenous CCK and the CCK-A receptors in the development of severe acute pancreatitis induced in Otsuka Long-Evans Tokushima Fatty (OLETF) rats that have a selective defect in the CCk-A receptor suggests that endogenous CCk and CCK
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Plasma cholecystokinin levels in acute pancreatitis.
Hisashi Shirohara,Makoto Otsuki +1 more
TL;DR: The present observations suggest that the increase in plasma CCK levels in gallstone pancreatitis appears to be the result of gallstone Pancitis probably due to a transient disturbance of bile flow into the duodenum by stones or edema of the bile duct.
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Effects of tetraprenylacetone on pancreatic exocrine secretion and acute pancreatitis in two experimental models in rats.
Issei Tachibana,Nobuaki Watanabe,Hisashi Shirohara,Toshiharu Akiyama,Shigekazu Nanano,Makoto Otsuki +5 more
TL;DR: It is concluded that TPN given by an oral route stimulates pancreatic exocrine secretion through an increase in endogenous secretin release and causes beneficial effects on the experimental model of mild acute pancreatitis in rats.