Journal ArticleDOI
High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidemia in normal adult male Wistar rat
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TLDR
Feeding of high-fat hypercaloric diet makes normal Wistar male adult rat obese associated with hyperlipidemia, hyperinsulinemia, and glucose intolerance, indicating the presence of insulin resistance.About:
This article is published in Diabetes Research and Clinical Practice.The article was published on 1996-03-01. It has received 157 citations till now. The article focuses on the topics: Insulin resistance & Triglyceride.read more
Citations
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Nonalcoholic fatty liver disease
TL;DR: A review of the clinical literature and selected basic information about NAFLD challenges some of the assumptions about the clinical importance of the disease.
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Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice.
Xing Xian Yu,Susan F. Murray,Sanjay K. Pandey,Sheri L. Booten,Dingjiu Bao,Xiu-Zhen Song,Susan Kelly,Songyuan Chen,Robert Mckay,Brett P. Monia,Sanjay Bhanot +10 more
TL;DR: Reduction of DGAT2 expression in obese animals can reduce hepatic lipogenesis and hepatic steatosis as well as attenuate hyperlipidemia, thereby leading to an improvement in metabolic syndrome.
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Fetal programming of appetite and obesity.
TL;DR: Whether postnatal obesity is a consequence of programming of appetite regulation and whether hyperphagia is the main underlying cause of the increased adiposity and the development of metabolic disorders is still unclear.
Journal ArticleDOI
Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet
Jamie W. Joseph,Vasilij Koshkin,Chen-Yu Zhang,Jing Wang,Bradford B. Lowell,Catherine B. Chan,Michael B. Wheeler +6 more
TL;DR: Beta-cell function in UCP2-deficient mice was examined after a 45% high-fat diet to assess its role during the development of diet-induced type 2 diabetes and a possible new aspect of U CP2 function is suggested.
Journal ArticleDOI
Fat Intake Affects Adiposity, Comorbidity Factors, and Energy Metabolism of Sprague‐Dawley Rats
TL;DR: The hypothesis that administration of increasing amount of dietary fat to very young rats enhances susceptibility to diet-induced obesity and its comorbidities is supported.
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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A simple, rapid, and sensitive DNA assay procedure.
C Labarca,Kenneth Paigen +1 more
TL;DR: The dissociation of chromatin is critical to accurate determinations of DNA in biological materials using this method, which can detect as little as 10 ng of DNA with rather unsophisticated instrumentation.
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The preparation and properties of two new chromogenic substrates of trypsin.
TL;DR: Preliminary studies indicate that benzoyl dl -arginine p -nitroanilide hydrochloride is also hydrolyzed by papain, and that of l -LPA is in a more alkaline region than normally found for trypsin substrates.
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Cholecystokinin decreases food intake in rats.
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Spontaneous Long-Term Hyperglycemic Rat With Diabetic Complications: Otsuka Long-Evans Tokushima Fatty (OLETF) Strain
TL;DR: Clinical and pathological features of disease in OLETF rats resemble those of human NIDDM.