Hitoshi Kurose

TL;DR: It is observed that in the presence of low concentrations of the alpha 2AR agonist UK-14304, alpha 2C10 mediated inhibition of adenylyl cyclase activity, whereas at high concentrations of agonist,alpha 2C 10 mediated stimulation of adencylylcyclase activity.

TL;DR: The findings strengthen the idea that constitutively active adrenergic receptors mimic the "active" state of a G protein-coupled receptor adopting conformations similar to those induced by agonist when it binds to wild type receptors.

TL;DR: The results indicate that the A-subtype ofα2AR is distributed widely within brain and reflects the presence of newly synthesizedα2AAR in perikarya as well as those receptors along the plasma membrane ofperikarya, dendritic trunks and spines; and α2A AR in LC may operate as heteroreceptors on non-catecholaminergic terminals aswell as autoreceptor on noradrenergic terminals.

TL;DR: Long term agonist-induced desensitization of alpha 2AAR was found to be due in part to a decrease in the amount of cellular Gi, which was not dependent on receptor third loop phosphorylation sites.

TL;DR: Heterotrimeric G proteins may represent a previously unappreciated class of potential substrates for pp60c-src and G proteins with functional consequences, and are explored in this study.