H
Hitoshi Nakatogawa
Researcher at Tokyo Institute of Technology
Publications - 76
Citations - 18888
Hitoshi Nakatogawa is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Autophagy & ATG8. The author has an hindex of 36, co-authored 70 publications receiving 15280 citations. Previous affiliations of Hitoshi Nakatogawa include National Presto Industries & Graduate University for Advanced Studies.
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Journal ArticleDOI
Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy.
Noriko Kondo-Okamoto,Nobuo N. Noda,Sho W. Suzuki,Hitoshi Nakatogawa,Ikuko Takahashi,Miou Matsunami,Ayako Hashimoto,Fuyuhiko Inagaki,Yoshinori Ohsumi,Koji Okamoto +9 more
TL;DR: It is shown that the Atg32 IMS domain is dispensable for mitophagy, and it is demonstrated that atg32 forms a complex with Atg8 and Atg11 prior to and independent of isolation membrane generation and subsequent autophagosome formation.
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Autophagy-related Protein 8 (Atg8) Family Interacting Motif in Atg3 Mediates the Atg3-Atg8 Interaction and Is Crucial for the Cytoplasm-to-Vacuole Targeting Pathway
Masaya Yamaguchi,Nobuo N. Noda,Hitoshi Nakatogawa,Hitoshi Nakatogawa,Hiroyuki Kumeta,Yoshinori Ohsumi,Fuyuhiko Inagaki +6 more
TL;DR: It is shown that Atg3 directly interacts with Atg8 through the WEDL sequence, which is distinct from canonical interaction between E2 and ubiquitin-like modifiers, and is a canonical AIM.
Journal ArticleDOI
Hrr25 triggers selective autophagy–related pathways by phosphorylating receptor proteins
Chikara Tanaka,Li-Jing Tan,Keisuke Mochida,Hiromi Kirisako,Michiko Koizumi,Eri Asai,Machiko Sakoh-Nakatogawa,Yoshinori Ohsumi,Hitoshi Nakatogawa +8 more
TL;DR: The budding yeast kinase Hrr25 regulates two selective autophagy–related pathways by phosphorylating degradation target receptors and thereby promoting their interaction with Atg11 and the formation of autophagosomal membrane.
Journal ArticleDOI
The Autophagy-related Protein Kinase Atg1 Interacts with the Ubiquitin-like Protein Atg8 via the Atg8 Family Interacting Motif to Facilitate Autophagosome Formation
Hitoshi Nakatogawa,Shiran Ohbayashi,Machiko Sakoh-Nakatogawa,Soichiro Kakuta,Sho W. Suzuki,Hiromi Kirisako,Chika Kondo-Kakuta,Nobuo N. Noda,Hayashi Yamamoto,Yoshinori Ohsumi +9 more
TL;DR: It is proposed that in addition to its essential function in the initial stage, Atg1 also associates with the isolation membrane to promote its maturation into the autophagosome, distinct from its role for triggering the process.
Autophagy-related protein 32 as autophagic degron and directly initiates mitophagy. ; Autophagy-related Protein 32 Acts as Autophagic Degron and Directly Initiates Mitophagy
Noriko Kondo-Okamoto,Nobuo N. Noda,Sho W. Suzuki,Hitoshi Nakatogawa,中戸川仁,Ikuko Takahashi,Miou Matsunami,Ayako Hashimoto,Fuyuhiko Inagaki,Yoshinori Ohsumi,大隅 良典,Koji Okamoto +11 more
TL;DR: The Atg32 IMS domain is dispensable for mitophagy in yeast as discussed by the authors, and it is shown that Atg8 and Atg11 are not necessary and sufficient for initiation of autophagosome formation.