H
Hmd Gurling
Researcher at University College London
Publications - 17
Citations - 191
Hmd Gurling is an academic researcher from University College London. The author has contributed to research in topics: Locus (genetics) & Genetic linkage. The author has an hindex of 7, co-authored 17 publications receiving 189 citations.
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Journal ArticleDOI
Genome scan of Tourette syndrome in a single large pedigree shows some support for linkage to regions of chromosomes 5, 10 and 13.
David Curtis,Peter Brett,A M Dearlove,Andrew McQuillin,Gursharan Kalsi,Mary M. Robertson,Hmd Gurling +6 more
TL;DR: It seems likely that more than one susceptibility allele is present in the pedigree, and it seems probable that at least one contains a susceptibility locus.
Journal ArticleDOI
No evidence of expansion of CAG or GAA repeats in schizophrenia families and monozygotic twins.
John B. Vincent,Gursharan Kalsi,T. Klempan,Y Tatuch,Robin Sherrington,T. Breschel,Melvin G. McInnis,J Brynjolfsson,H Petursson,H Petursson,Hmd Gurling,Irving I. Gottesman,E.F. Torrey,A Petronis,Juliet Kennedy +14 more
TL;DR: Results suggest that trinucleotide repeats found in 12 families from the United Kingdom and Iceland are not involved in the etiology of schizophrenia, and the techniques used for detecting repeat expansions have limits to their sensitivity.
No allelic association between bipolar affective disorder and the tryptophan hydroxylase gene (TPH).
Journal ArticleDOI
Linkage Analysis of Manic Depression (Bipolar Affective Disorder) in Icelandic and British Kindreds using Markers on the Short Arm of Chromosome 18
Gursharan Kalsi,C Smyth,J Brynjolfsson,R Sherrington,Jane O'Neill,David Curtis,Larry Rifkin,Patrick B. Murphy,Hannes Petursson,Hmd Gurling +9 more
TL;DR: This study provides no support for the presence of a locus-modifying genetic susceptibility to bipolar affective disorder in the pericentromeric region of chromosome 18q11.
Journal ArticleDOI
Exclusion of linkage of schizophrenia to the gene for the dopamine D2 receptor (DRD2) and chromosome 11q translocation sites
Gursharan Kalsi,Bs Mankoo,David Curtis,J Brynjolfsson,T Read,Tonmoy Sharma,Patrick B. Murphy,Hannes Petursson,Hmd Gurling +8 more
TL;DR: Three 11q DNA markers were used to investigate 23 pedigrees containing multiple cases of schizophrenia, providing evidence against linkage over a 70 cM region which included both translocation sites and both candidate genes.