H
Hong D. Xiao
Researcher at Emory University
Publications - 29
Citations - 1776
Hong D. Xiao is an academic researcher from Emory University. The author has contributed to research in topics: Angiotensin-converting enzyme & Angiotensin II. The author has an hindex of 16, co-authored 29 publications receiving 1630 citations. Previous affiliations of Hong D. Xiao include Mayo Clinic & Harvard University.
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Journal ArticleDOI
ACE and ACE2 Activity in Diabetic Mice
Jan Wysocki,Minghao Ye,María José Soler,Susan B. Gurley,Hong D. Xiao,Kenneth E. Bernstein,Thomas M. Coffman,Sheldon Chen,Daniel Batlle +8 more
TL;DR: In renal cortex from diabetic mice, ACE2 expression is increased at the posttranscriptional level, and this should be helpful in the evaluation of kidney-specific alterations in the balance of these two carboxypeptidases.
Journal ArticleDOI
Mice with Cardiac-Restricted Angiotensin-Converting Enzyme (ACE) Have Atrial Enlargement, Cardiac Arrhythmia, and Sudden Death
Hong D. Xiao,Sebastien Fuchs,Duncan J. Campbell,William Lewis,Samuel C. Dudley,Vijaykumar S. Kasi,Brian D. Hoit,George Keshelava,Hui Zhao,Mario R. Capecchi,Kenneth E. Bernstein +10 more
TL;DR: Increased local production of angiotensin II in the heart is not sufficient to induce ventricular hypertrophy or fibrosis, and it leads to atrial morphological changes, cardiac arrhythmia, and sudden death.
Journal ArticleDOI
Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction
Gad A. Silberman,Tai Hwang M. Fan,Hong Liu,Hong Liu,Zhe Jiao,Zhe Jiao,Hong D. Xiao,Joshua D. Lovelock,Beth M. Boulden,Julian D. Widder,Scott Fredd,Kenneth E. Bernstein,Beata M. Wolska,Sergey Dikalov,David G. Harrison,Samuel C. Dudley +15 more
TL;DR: Cardiac oxidation, independently of vascular changes, can lead to uncoupled cardiac NOS and diastolic dysfunction, and BH4 may represent a possible treatment for diastolics dysfunction.
Journal ArticleDOI
Regulation of Steady-state β-Amyloid Levels in the Brain by Neprilysin and Endothelin-converting Enzyme but Not Angiotensin-converting Enzyme
Elizabeth A. Eckman,Stephanie K. Adams,Frederick J. Troendle,Becky A. Stodola,Murad A. Kahn,Abdul H. Fauq,Hong D. Xiao,Kenneth E. Bernstein,Christopher B. Eckman +8 more
TL;DR: The results of these studies do not support a physiological role for ACE in the degradation of β-amyloid in the brain but confirm roles for endothelin-converting enzyme and neprilysin and indicate that reductions in these enzymes result in additive increases in brain amyloid β-peptide levels.
Journal ArticleDOI
Angiotensin-Converting Enzyme C-Terminal Catalytic Domain Is the Main Site of Angiotensin I Cleavage In Vivo
Sebastien Fuchs,Hong D. Xiao,Christine Hubert,Annie Michaud,Duncan J. Campbell,Jonathan Adams,Mario R. Capecchi,Pierre Corvol,Kenneth E. Bernstein +8 more
TL;DR: It is shown that the C-domain of ACE is the predominant site of angiotensin I cleavage in vivo, and although mice lacking C- domain activity have normal physiology under laboratory conditions, they respond less well to the stress of dehydration.