K
Kenneth E. Bernstein
Researcher at Cedars-Sinai Medical Center
Publications - 253
Citations - 14388
Kenneth E. Bernstein is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Angiotensin II & Angiotensin-converting enzyme. The author has an hindex of 60, co-authored 222 publications receiving 12953 citations. Previous affiliations of Kenneth E. Bernstein include Emory University & National Institutes of Health.
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Journal ArticleDOI
Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
TL;DR: The isolation by expression cloning of a complementary DNA encoding a unique protein with the pharmacological specificity of a vascular AT1 receptor is reported, and hydropathic modelling of the deduced protein suggests that it shares the seven-transmembrane-region motif with the G protein-coupled receptor superfamily.
Journal ArticleDOI
Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor.
Mario B. Marrero,Bernhard Schieffer,William G. Paxton,Lauri Heerdt,Bradford C. Berk,Patrick Delafontaine,Kenneth E. Bernstein +6 more
TL;DR: It is shown here that angiotensin II induces the rapid phosphorylation of tyrosine in the intracellular kinases Jak2 and Tyk2 in rat aortic smooth-muscle cells and that thisosphorylation is associated with increased activity of Jak2.
Journal Article
Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility
Charles R. Esther,Tom E. Howard,Elaine M. Marino,Judy M. Goddard,Mario R. Capecchi,Kenneth E. Bernstein +5 more
TL;DR: ACE-deficient animals demonstrate the role of this enzyme in systemic blood pressure, renal development and function, and male fertility as well as the importance of testis ACE in male fertility.
Journal ArticleDOI
DC isoketal-modified proteins activate T cells and promote hypertension
Annet Kirabo,Vanessa Fontana,Ana Paula Faria,Roxana Loperena,Christi L Galindo,Jing Wu,Alfiya T Bikineyeva,Sergey Dikalov,Liang Xiao,Wei Chen,Mohamed A. Saleh,Daniel W. Trott,Hana A. Itani,Antony Vinh,Venkataraman Amarnath,Kalyani Amarnath,Tomasz J. Guzik,Kenneth E. Bernstein,Xiao Z. Shen,Yu Shyr,Sheau-Chiann Chen,Raymond L. Mernaugh,Cheryl L. Laffer,Fernando Elijovich,Sean S. Davies,Heitor Moreno,Meena S. Madhur,L. Jackson Roberts,David G. Harrison +28 more
TL;DR: The data reveal that hypertension activates dendritic cell activation of T cells, in large part by promoting the formation of isoketals, and suggest that reducing isokets has potential as a treatment strategy for this disease.
Journal ArticleDOI
ACE and ACE2 Activity in Diabetic Mice
Jan Wysocki,Minghao Ye,María José Soler,Susan B. Gurley,Hong D. Xiao,Kenneth E. Bernstein,Thomas M. Coffman,Sheldon Chen,Daniel Batlle +8 more
TL;DR: In renal cortex from diabetic mice, ACE2 expression is increased at the posttranscriptional level, and this should be helpful in the evaluation of kidney-specific alterations in the balance of these two carboxypeptidases.