H
Hong Liu
Researcher at National Health and Family Planning Commission
Publications - 8
Citations - 176
Hong Liu is an academic researcher from National Health and Family Planning Commission. The author has contributed to research in topics: Autophagy & Signal transduction. The author has an hindex of 6, co-authored 8 publications receiving 137 citations. Previous affiliations of Hong Liu include Peking Union Medical College.
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Journal ArticleDOI
SPHK1 (sphingosine kinase 1) induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells.
TL;DR: A novel mechanism responsible for the regulation of the EMT via SPHK1-TRAF2-BECN1-CDH1 signal cascades in HCC cells is defined and indicates that the blockage of SP HK1 activity to attenuate autophagy may be a promising strategy for the prevention and treatment of HCC.
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Involvement of Ras GTPase-activating protein SH3 domain-binding protein 1 in the epithelial-to-mesenchymal transition-induced metastasis of breast cancer cells via the Smad signaling pathway
Hao Zhang,Yan Ma,Shenghua Zhang,Hong Liu,Hongwei He,Naren Li,Yuyan Gong,Shuangshuang Zhao,Jian-Dong Jiang,Rong-Guang Shao +9 more
TL;DR: A novel function of G3BP1 is identified in the progression of breast cancer via activation of the EMT, indicating that G3 BP1 might represent a potential therapeutic target for metastatic human breast cancer.
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D-chiro-inositol effectively attenuates cholestasis in bile duct ligated rats by improving bile acid secretion and attenuating oxidative stress.
Zhao Shuangshuang,Li Naren,Wuli Zhao,Hong Liu,Ge Maoxu,Yi-Xuan Zhang,Long-Yin Zhao,Xuefu You,He Hongwei,Rong-Guang Shao +9 more
TL;DR: D-chiro-inositol (DCI) effectively attenuates BDL-induced hepatic bile acid accumulation and decreases the severity of injury and fibrosis by improving bile Acid secretion, repressing inflammation and decreasing oxidative stress.
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Phosphorylation of myofibrillogenesis regulator-1 activates the MAPK signaling pathway and induces proliferation and migration in human breast cancer MCF7 cells
TL;DR: It is reported that MR‐1 is overexpressed inhuman breast cancer cells and participates in tumor promotion in human breast cancer MCF7 cells by activating the ERK1/2 signaling pathway.
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EBP50 suppresses the proliferation of MCF-7 human breast cancer cells via promoting Beclin-1/p62-mediated lysosomal degradation of c-Myc
TL;DR: It is demonstrated that the EBP50/Beclin-1/p62/c-Myc signaling pathway plays a role in the proliferation in MCF-7 breast cancer cells: E BP50 stimulates the autophagic lysosomal degradation of c- myc, thereby inhibits the proliferation of MCF -7 cells.