Honghua Yu

TL;DR: It is shown that elevation of intraocular pressure induces T cell infiltration in the eyes and that T cell cross-reactivity between endogenous and commensal antigens contributes to disease onset in mice, providing compelling evidence that glaucomatous neurodegeneration is mediated in part by T cells that are pre-sensitized by exposure to commensals microflora.

TL;DR: Functional and structural impairments have already started in diabetic retina even in the absence of visible retinal lesions, and Subtle microvascular abnormalities rather than ganglion cell loss might be associated with early functional changes in NDR patients.

TL;DR: The levels of inflammatory cytokine levels were increased in DR patients and might have a synergistic effect on the pathogenesis of this disease, and they were elevated along with the progression of neovascularization, reflecting the severity of DR.

TL;DR: The authors showed that T-cell infiltration into the retina leads to a prolonged phase of retinal ganglion cell degeneration that persists after IOP returns to a normal level, indicating that glaucomatous neurodegeneration is mediated in part by T cells that are pre-sensitized by exposure to commensal microflora.

TL;DR: Whether neural or vascular defects occur first in the early onset of diabetic retinopathy (DR) is undetermined.