H
Honglei Chen
Researcher at Wuhan University
Publications - 68
Citations - 1556
Honglei Chen is an academic researcher from Wuhan University. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 21, co-authored 60 publications receiving 1156 citations. Previous affiliations of Honglei Chen include Rush University Medical Center.
Papers
More filters
Journal ArticleDOI
The promising immune checkpoint LAG-3: from tumor microenvironment to cancer immunotherapy.
TL;DR: Light is shed on the significance of LAG-3 in the tumor microenvironment, its role to regulate different lymphocytes, interplay with other immune checkpoints especially PD-1, and emphasize new advances in L AG-3-targeted immunotherapy.
Journal ArticleDOI
Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6.
Haixia Zhao,Xinhua Zhang,Xuewei Chen,Ying Li,Zunqiong Ke,Tian Tang,Hongyan Chai,Austin M. Guo,Honglei Chen,Jing Yang +9 more
TL;DR: In summary, dietary flavonoid ISL effectively inhibits colitis-associated tumorigenesis through hampering M2 macrophage polarization mediated by the interplay between PGE2 and IL-6.
Journal ArticleDOI
The prognostic value of autophagy-related markers beclin-1 and microtubule-associated protein light chain 3B in cancers: a systematic review and meta-analysis
TL;DR: This systematic review and meta-analysis indicated that the autophagy-related marker BECN1 might be a predictive factor of favorable prognosis in gastric cancer, breast cancer, and lymphoma and LC3B might predict unfavorable prognosis of breast cancer.
Journal ArticleDOI
Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1
Chenlong Wang,Yaxin Chen,Wang Yang,Xiaoxiao Liu,Yanzhuo Liu,Ying Li,Honglei Chen,Chengpeng Fan,Dongfang Wu,Jing Yang +9 more
TL;DR: Reprogramming COX-2, mPGES-1 and CYP4A mediated-AA metabolism in glioma by flavonoid ISL inhibits the angiogenic Akt- FGF-2/TGF-β/VEGF signaling through ceRNA effect of miR-194-5p and lncRNA NEAT1, and may serve as a novel therapeutic strategy for humanglioma.
Journal ArticleDOI
Inhibiting tumor necrosis factor-alpha diminishes desmoplasia and inflammation to overcome chemoresistance in pancreatic ductal adenocarcinoma
Xianda Zhao,Xianda Zhao,Wei Fan,Zhigao Xu,Honglei Chen,Yuyu He,Yuyu He,Gui Yang,Gang Yang,Hanning Hu,Shihui Tang,Ping Wang,Zheng Zhang,Peipei Xu,Mingxia Yu +14 more
TL;DR: Inhibition of TNF-α synergized with chemotherapy in PDAC resulted in better pre-clinical responses via killing tumor cells as well as diminishing desmoplasia and inflammation inPDAC tumor stroma.