Hongtao Yu

TL;DR: It is concluded that SH3 domains recognize proline-rich motifs possessing the left-handed type II polyproline (PPII) helix conformation, and these motifs appear to function as a molecular scaffold, promoting the formation of the PPII helix.

TL;DR: The model was used to identify correctly both the binding orientation and the contact and noncontact residues of a peptide derived from the nucleotide exchange factor Sos in association with the amino-terminal SH3 domain of the adaptor protein Grb2.

TL;DR: The initial functional analysis of a poorly characterized human lncRNA that is induced after DNA damage is described, introducing a mechanism that regulates the activity of a deeply conserved and highly dosage-sensitive family of RNA binding proteins and reveal unanticipated roles for a lnc RNA and PUMILIO proteins in the maintenance of genomic stability.

TL;DR: It is shown that the checkpoint-mediated cell cycle arrest involves hMAD2 receiving an upstream signal to inhibit activation of APC, and a change in hM AD2 structure may play a role in transducing the checkpoint signal.

TL;DR: This work reviews recent progress toward the understanding of the molecular mechanism of the spindle checkpoint and its role in guarding genome integrity at the chromosome level and describes the current state of research in this area.