Indoles in multicomponent processes (MCPs).

Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy.

Histone deacetylase inhibitors

Recent Progress in Three-Component Reactions. An Update

Pseudo-C3-symmetric trisoxazoline copper(II) complexes prove to be excellent catalysts in the Friedel−Crafts alkylation of indoles with alkylidene malonates. The absolute stereochemistry of this re...

Controllable Enantioselective Friedel−Crafts Reaction1 between Indoles and Alkylidene Malonates Catalyzed by Pseudo-C3-Symmetric Trisoxazoline Copper(II) Complexes

An efficient catalytic asymmetric Friedel-Crafts alkylation of indoles with alkylidene malonates has been developed by using a chiral N,N'-dioxide-Sc(OTf)(3) complex as the catalyst (see scheme). Some optically active intermediates containing the indole skeleton have been synthesized, such as indolepropionic acid, tryptamines, and beta-carbolines. The coordination between the scandium atom and the chiral N,N'-dioxide compound has been revealed by X-ray structure analysis.

Enantioselective Friedel–Crafts Alkylation of Indoles with Alkylidene Malonates Catalyzed by N,N′‐Dioxide–Scandium(III) Complexes: Asymmetric Synthesis of β‐Carbolines

Houria Seghir

Papers

A Convenient Synthesis of Conformationally Constrained β-Substituted Tryptophans