J
Jean-Yves Laronze
Researcher at University of Reims Champagne-Ardenne
Publications - 76
Citations - 727
Jean-Yves Laronze is an academic researcher from University of Reims Champagne-Ardenne. The author has contributed to research in topics: Indole test & Ring (chemistry). The author has an hindex of 15, co-authored 76 publications receiving 715 citations. Previous affiliations of Jean-Yves Laronze include Centre national de la recherche scientifique.
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Improved gelatinase a selectivity by novel zinc binding groups containing galardin derivatives.
TL;DR: The synthesis of several analogues of galardin, a MMP inhibitor, are presented with their in vitro inhibitory activity against MMP-1 and M MP-2, and those that are based on a hydrazide scaffold present potent selectivity for MMP
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Indole based multicomponent reactions towards functionalized heterocycles
Janos Sapi,Jean-Yves Laronze +1 more
TL;DR: A short review of the indole ring implicated multicomponent reactions, and simple functional group transformation-based approaches, developed over the last thirty years for the synthesis of various biologically interesting indole heterocyclic ring systems is given in this article.
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A Convenient Synthesis of Conformationally Constrained β-Substituted Tryptophans
Csaba Nemes,Laurent Jeannin,Janos Sapi,Marie Laronze,Houria Seghir,Franck Augé,Jean-Yves Laronze +6 more
TL;DR: In this paper, a short and general synthesis for the preparation of various conformationally constrained β-substituted tryptophans has been elaborated starting from indole, aldehydes and Meldrum's acid by using trimolecular condensation and Curtius rearrangement mediated functional group transformations followed by deprotections, as key-steps.
Journal ArticleDOI
Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity
Gwennaël LeDour,Gautier Moroy,Matthieu Rouffet,Erika Bourguet,Dominique Guillaume,Martine Decarme,Haquima ElMourabit,Franck Augé,Alain J.P. Alix,Jean-Yves Laronze,Georges Bellon,William Hornebeck,Janos Sapi +12 more
TL;DR: Hydrazide derivatives of Ilomastat, carrying either aryl groups or distinct alkyl and arylsulfonyl moieties were synthesized and evaluated for their MMP inhibitory activity.