Howard C.B. Graves

TL;DR: It is speculated that PSA may serve to modulate IGF function within the reproductive system or in prostate cancer by altering IGF-IGFBP-3 interactions.

TL;DR: ISMS of PSA is proposed as a convenient and reliable method of quality control, an indispensible step towards international standardization of this very important tumor marker for detection and monitoring of prostatic diseases, especially prostate cancer.

TL;DR: It is concluded that the first voided urine sample better reflects local PSA production by the prostate than the midstream sample, first Voided urine PSA decreases significantly in response to radical prostatectomy but is still present in measurable amounts even in surgically cured prostate cancer patients and urethral secretion of low levels of PSA persists after radical prostateCTomy.

TL;DR: Two leading commercial immunoassays for prostate specific antigen were compared using independently purified antigen as the calibrator, confirming that differences in assay values arise from differences in the assigned values of the kit calibrators.

TL;DR: It is concluded that an ultrasensitive assay for PSA can detect residual cancer after radical prostatectomy much earlier than current immunoassays for PRA, to improve long-term survival by allowing for earlier institution of adjuvant therapy.