H
Howard T. Holden
Researcher at National Institutes of Health
Publications - 81
Citations - 6751
Howard T. Holden is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cytotoxicity & Cytotoxic T cell. The author has an hindex of 35, co-authored 81 publications receiving 6721 citations. Previous affiliations of Howard T. Holden include Litton Industries & University of Perugia.
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Book ChapterDOI
Natural Cell-Mediated Immunity
TL;DR: This chapter summarizes the known information on the expression of natural cytotoxicity in rodents and in man, its specificity, the nature of the effector cells and their relationship to other immune mechanisms, and the possible in vivo relevance ofnatural cytotoxic relevance, particularly in regard to resistance against tumor growth.
Journal Article
Augmentation of Mouse Natural Killer Cell Activity by Interferon and Interferon Inducers
TL;DR: It is observed that pyran, lipopolysaccharide, and polyinosinicopolycytidylic acid as well as crude and purified IF preparations significantly elevated splenic NK levels in normal mice within 3 to 24 hr of i.p. administration, indicating that IF acts on lymphocytes to activate NK function.
Journal ArticleDOI
Natural Killer Cells: Characteristics and Regulation of Activity
Ronald B. Herberman,Ronald B. Herberman,Ronald B. Herberman,Julie Y. Djeu,Julie Y. Djeu,Julie Y. Djeu,H. David Kay,H. David Kay,H. David Kay,John R. Ortaldo,John R. Ortaldo,John R. Ortaldo,Carlo Riccardi,Carlo Riccardi,Carlo Riccardi,Guy D. Bonnard,Guy D. Bonnard,Guy D. Bonnard,Howard T. Holden,Howard T. Holden,Howard T. Holden,Roberto Fagnani,Roberto Fagnani,Roberto Fagnani,Angela Santoni,Paolo Puccetti,Paolo Puccetti,Paolo Puccetti +27 more
TL;DR: The views on the characteristics of NK cells are summarized and a few issues of current interest in the laboratory are focused on.
Journal Article
Inhibition of murine natural killer cell activity by prostaglandins.
Journal ArticleDOI
Evidence of suppressor cell activity in spleens of mice bearing primary tumors induced by moloney sarcoma virus
TL;DR: The data show, that a tumor, although stimulating the immune system, nevertheless may be suppressive on certain immune functions through the activation of suppressor cells.