Hsing-Chuan Tsai

TL;DR: FTY720 (fingolimod), a non-selective S1PR modulator, significantly decreased annualized relapse rates in relapsing-remitting multiple sclerosis (MS), and recent studies suggest that FTY720 also decreases astrogliosis and promotes oligodendrocyte differentiation within the CNS and may have therapeutic benefit to prevent brain atrophy.

TL;DR: Recent advances in unraveling the mechanism behind Th17 cell differentiation, IL-17A/IL-17R signaling, and also the importance of IL- 17A in pulmonary infection are summarized.

TL;DR: This paper showed that pericytes regulate the development of organ-specific characteristics of the brain vasculature such as the blood-brain barrier (BBB) and astrocytic end-feet and showed that myelin peptide-specific peripheral T cells in Pdgfb ret/ret ;2D2 tg mice lead to the development spontaneous neurological symptoms paralleled by the massive influx of leukocytes into the brain.

TL;DR: It is shown that pericytes indirectly restrict immune cell transmigration into the CNS under homeostatic conditions and during autoimmune-driven neuroinflammation by inducing immune quiescence of brain endothelial cells.

TL;DR: It is found that mice carrying a phosphorylation-defective S1pr1 gene [S1PR1(S5A) mice] were refractory to FTY720 treatment in MOG35-55-immunized and Th17-mediated experimental autoimmune encephalomyelitis (EAE) models, suggesting that cell type-specific therapies may enhance therapeutic efficacy in MS.