O
Orsolya Török
Researcher at University of Zurich
Publications - 3
Citations - 115
Orsolya Török is an academic researcher from University of Zurich. The author has contributed to research in topics: PDGFB & Leukocyte Trafficking. The author has an hindex of 2, co-authored 2 publications receiving 20 citations.
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Journal ArticleDOI
Pericytes regulate vascular immune homeostasis in the CNS.
Orsolya Török,Bettina Schreiner,Johanna Schaffenrath,Hsing-Chuan Tsai,Upasana Maheshwari,Sebastian A. Stifter,Christina Welsh,Ana Amorim,Sucheta Sridhar,Sebastian G. Utz,Wiebke Mildenberger,Sina Nassiri,Mauro Delorenzi,Adriano Aguzzi,May H. Han,Melanie Greter,Burkhard Becher,Annika Keller +17 more
TL;DR: This paper showed that pericytes regulate the development of organ-specific characteristics of the brain vasculature such as the blood-brain barrier (BBB) and astrocytic end-feet and showed that myelin peptide-specific peripheral T cells in Pdgfb ret/ret ;2D2 tg mice lead to the development spontaneous neurological symptoms paralleled by the massive influx of leukocytes into the brain.
Posted ContentDOI
Pericytes regulate vascular immune homeostasis in the CNS
Orsolya Török,Bettina Schreiner,Hsing-Chuan Tsai,Sebastian G. Utz,Johanna Schaffenrath,Sina Nassiri,Mauro Delorenzi,Adriano Aguzzi,May H. Han,Melanie Greter,Burkhard Becher,Annika Keller +11 more
TL;DR: It is shown that pericytes indirectly restrict immune cell transmigration into the CNS under homeostatic conditions and during autoimmune-driven neuroinflammation by inducing immune quiescence of brain endothelial cells.
Journal ArticleDOI
Bone Marrow-Derived BRAFV600E-Mutated Cells Drive Neurodegeneration in a Mouse Model of Langerhans Cell Histiocytosis
Christian Matthias Wilk,Jessica LeBerichel,Flurin Cathomas,George Heaton,Orsolya Török,Aymeric Silvin,Zhenyu Yue,Scott J. Russo,Florent Ginhoux,Jennifer Picarsic,Carl E. Allen,Miriam Merad +11 more
TL;DR: In this paper , the authors used BM chimera to study the transition of BRAFV600E-mutated cells to the brain as well as mechanisms of neurologic damage therein, and they concluded that BM-derived myeloid progenitors reproducibly invade brain parenchyma where they differentiate into macrophages and induce inflammation and CNS injury.