H
Hsueh-Cheng Huang
Researcher at Merck & Co.
Publications - 21
Citations - 320
Hsueh-Cheng Huang is an academic researcher from Merck & Co.. The author has contributed to research in topics: Indole test & Replicon. The author has an hindex of 10, co-authored 21 publications receiving 296 citations. Previous affiliations of Hsueh-Cheng Huang include Schering-Plough.
Papers
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Journal ArticleDOI
I. Novel HCV NS5B polymerase inhibitors: Discovery of indole 2-carboxylic acids with C3-heterocycles
Gopinadhan N. Anilkumar,Charles A. Lesburg,Oleg Selyutin,Stuart B. Rosenblum,Qingbei Zeng,Yueheng Jiang,Tin Yau Chan,Haiyan Pu,Henry M. Vaccaro,Li Wang,Frank Bennett,Kevin X. Chen,Jose S. Duca,Stephen Gavalas,Yuhua Huang,Pinto Patrick A,Mousumi Sannigrahi,Francisco Velazquez,Srikanth Venkatraman,Bancha Vibulbhan,Sony Agrawal,Nancy Butkiewicz,Boris Feld,Eric Ferrari,Zhiqing He,Chuan Kui Jiang,Robert E. Palermo,Patricia McMonagle,Hsueh-Cheng Huang,Neng Yang Shih,George F Njoroge,Joseph A. Kozlowski +31 more
TL;DR: SAR development of indole-based palm site inhibitors of HCV NS5B polymerase exemplified by initial indole lead 1 (NS5B IC(50)=0.9 μM, replicon EC(50)>100 μM) is described.
Patent
2, 3-substituted indole derivatives for treating viral infections
Gopinadhan N. Anilkumar,Bennett Frank,Chan Tin Yau,Kevin X. Chen,Mousumi Sannigrahi,Velazquez Francisco,Srikanth Venkatraman,Qingbei Zeng,Jose S. Duca,Charles A. Lesburg,Joseph A. Kozlowski,Njoroge F George,Stuart B. Rosenblum,Shih Neng-Yang,Stephen Gavalas,Yueheng Jiang,Pinto Patrick A,Haiyan Pu,Oleg Selyutin,Bancha Vibulbhan,Wang Li,Wanli Wu,Weiying Yang,Yuhua Huang,Hsueh-Cheng Huang,Robert E. Palermo,Boris Feld +26 more
TL;DR: In this article, a 2,3-substituted indole derivative for treating or preventing a viral infection or a virus-related disorder in a patient is described. But the method of using the 2 3-substantituted Indole derivative is not described.
Journal ArticleDOI
Structure–Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase
Kevin X. Chen,Bancha Vibulbhan,Weiying Yang,Mousumi Sannigrahi,Francisco Velazquez,Tin-Yau Chan,Srikanth Venkatraman,Gopinadhan N. Anilkumar,Qingbei Zeng,Frank Bennet,Yueheng Jiang,Charles A. Lesburg,Jose S. Duca,Pinto Patrick A,Stephen Gavalas,Yuhua Huang,Wanli Wu,Oleg Selyutin,Sony Agrawal,Boris Feld,Hsueh-Cheng Huang,Cheng Li,K.-C. Cheng,Neng-Yang Shih,Joseph A. Kozlowski,Stuart B. Rosenblum,F. George Njoroge +26 more
TL;DR: The identification of compound 56, which had an excellent potency in both NS5B enzyme and cell-based replicon assays and a good oral PK profile with area-under-the curve (AUC) of 14 and 8 μM·h in rats and dogs, respectively, was reported.
Journal ArticleDOI
Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides.
Cliff C. Cheng,Gerald W. Shipps,Zhiwei Yang,Noriyuki Kawahata,Charles A. Lesburg,Jose S. Duca,Jamie Bandouveres,Jack D. Bracken,Chuan-kui Jiang,Sony Agrawal,Eric Ferrari,Hsueh-Cheng Huang +11 more
TL;DR: The crystal structure of an analogue was solved and provided rationalization of the SAR of this series of non-nucleoside inhibitors targeting the HCV polymerase, which binds in a distinct manner in the palm domain of NS5B consistent with biochemical analysis using enzyme mutant variants.
Journal ArticleDOI
A novel class of highly potent irreversible hepatitis C virus NS5B polymerase inhibitors.
Kevin X. Chen,Charles A. Lesburg,Bancha Vibulbhan,Weiying Yang,Tin-Yau Chan,Srikanth Venkatraman,Francisco Velazquez,Qingbei Zeng,Frank Bennett,Gopinadhan N. Anilkumar,Jose S. Duca,Yueheng Jiang,Pinto Patrick A,Li Wang,Yuhua Huang,Oleg Selyutin,Stephen Gavalas,Haiyan Pu,Sony Agrawal,Boris Feld,Hsueh-Cheng Huang,Cheng Li,K.-C. Cheng,Neng-Yang Shih,Joseph A. Kozlowski,Stuart B. Rosenblum,F. George Njoroge +26 more
TL;DR: The NMR ALARM assay, mass spectroscopy experiments, in vitro counter screening, and toxicology assays demonstrated that the covalent bond formation between compound 47 and the protein was highly selective and specific.