H
Hua Zhu
Researcher at Peking Union Medical College
Publications - 4
Citations - 32
Hua Zhu is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 2, co-authored 2 publications receiving 8 citations.
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Journal ArticleDOI
Reg4 and complement factor D prevent the overgrowth of E. coli in the mouse gut.
Houbao Qi,Jianmei Wei,Yunhuan Gao,Yazheng Yang,Yuanyuan Li,Hua Zhu,Lei Su,Xiaomin Su,Yuan Zhang,Rongcun Yang +9 more
TL;DR: It is demonstrated that gut complement factor D (CFD) plays an important role in eliminating E. coli and that gut Reg4, which is expressed in gut epithelial cells, stimulated complement-mediated attack complexes to eliminate E. Escherichia coli.
Journal ArticleDOI
Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli.
Houbao Qi,Yunhuan Gao,Yuanyuan Li,Jianmei Wei,Xiaomin Su,Chunze Zhang,Yingquan Liu,Hua Zhu,Lei Sui,Yanwen Xiong,Xi Yang,Yanmei Xu,Yuan Zhang,Rongcun Yang +13 more
TL;DR: It is found that increased E. coli in inflamed colon may induce inflammatory macrophages in gut and extra-gut tissues through a regulating network consisted of IL-18, IFN-γ, IL-12, and IL-22 in gut tissues.
Journal ArticleDOI
Optimizing the Method for Differentiation of Macrophages from Human Induced Pluripotent Stem Cells
Shanshan Li,Lili Song,Yingwen Zhang,Zhiyan Zhan,Yi Yang,Lisha Yu,Hua Zhu,Weihua Huang,Wanqiao Wang,Haizhong Feng,Yanxin Li +10 more
TL;DR: By optimizing the size control of embryoid bodies (EBs), this protocol provides an effective method for the generation of macrophages comparable to blood-derived macrophage, which provides potential value for cell therapy and gene editing studies.
Journal ArticleDOI
Induction of Senescence by Loss of Gata4 in Cardiac Fibroblasts
TL;DR: In this paper , the role of Gata4 in cardiac fibroblasts was investigated in vivo and in vitro, and it was shown that deletion of this transcription factor spontaneously induces cellular senescence in both cardiomyocytes and non-myocytes.