Huan Qi

TL;DR: A review of the literature on reactive oxygen species (ROS) and scavenging in cancer is presented in this article, where the authors discuss the related signal transduction networks and corresponding anticancer therapies.

TL;DR: 5-(3, 4, 5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl) imidazol (BZML) displayed potent cytotoxic activity against both A549 and A549/Taxol cells and was a poor substrate for P-glycoprotein (P-gp) and inhibited P-gp function by decreasing P- gp expression at the protein and mRNA levels.

TL;DR: The results uncover an undescribed mechanism where USP10, as a tumor suppressor, negatively regulates mTORC1 activation and AKT phosphorylation by stabilizing AMPKα and PTEN in HCC cells.

TL;DR: Investigating the interaction of SSD with the frequently overexpressed targets in TNBC led to the identification that it markedly suppressed Wnt/β-catenin signaling, but did not act on epidermal growth factor receptor and neurotensin receptor-1.

TL;DR: The substrates of F-box proteins are summarized, the important molecular mechanism and emerging role of F -box proteins especially from the perspective of cancer development and progression are discussed, and the potential role of E3 ubiquitin ligases as cancer biomarkers and therapeutic targets for future cancer treatment is suggested.