Huan Wang

TL;DR: This study substantially revises the understanding of the content of human follicular fluid and lays the foundation for the future investigation of the role of miRNAs in PCOS.

TL;DR: The data suggest that the common missense polymorphism rs710059 is associated with susceptibility to PCOS and that the Arg(264)Cys variant may increase aromatase enzymatic activity, which implies that aromat enzyme plays an important role in PCOS.

TL;DR: Direct evidence that methylation plays an important role in PCOS is provided and a novel role for EPHX1 in female reproduction is demonstrated, and knockdown and overexpression experiments in KGN cells showed that E PHX1 can regulate estradiol concentrations, and this indicates a role in steroidogenesis.

TL;DR: This study demonstrates that methylation levels of CpG sites in the FST promoter and 5'-UTR are not associated with PCOS, the first study to quantitatively evaluate the methylation Levels of a candidate gene in association with PCos.

TL;DR: Novel pathophysiological links between the GNRHR locus and thyroid function and insulin secretion in PCOS are suggested and common genetic variant in GNR HR contributes to the phenotypic expression of PCOS.