R
Ruizhi Feng
Researcher at Fudan University
Publications - 23
Citations - 997
Ruizhi Feng is an academic researcher from Fudan University. The author has contributed to research in topics: Medicine & Polycystic ovary. The author has an hindex of 10, co-authored 15 publications receiving 698 citations.
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Journal ArticleDOI
Identification of microRNAs in human follicular fluid: characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo.
Qing Sang,Zhongyuan Yao,Huan Wang,Ruizhi Feng,Haojue Wang,Xinzhi Zhao,Xinzhi Zhao,Qinghe Xing,Qinghe Xing,Li Jin,Lin He,Lin He,Lingqian Wu,Lei Wang,Lei Wang +14 more
TL;DR: This study substantially revises the understanding of the content of human follicular fluid and lays the foundation for the future investigation of the role of miRNAs in PCOS.
Journal ArticleDOI
Mutations in TUBB8 and Human Oocyte Meiotic Arrest
Ruizhi Feng,Qing Sang,Yanping Kuang,Xiaoxi Sun,Zheng Yan,Shaozhen Zhang,Juanzi Shi,Guoling Tian,Anna Luchniak,Yusuke Fukuda,Bin Li,Min Yu,Junling Chen,Yao Xu,Luo Guo,Ronggui Qu,Xueqian Wang,Zhaogui Sun,Miao Liu,Huijuan Shi,Hongyan Wang,Yi Feng,Ruijin Shao,Renjie Chai,Qiaoli Li,Qinghe Xing,Rui Zhang,Eva Nogales,Li Jin,Lin He,Mohan L. Gupta,Nicholas J. Cowan,Lei Wang +32 more
TL;DR: Seven mutations in the primate-specific gene TUBB8 that were responsible for oocyte meiosis I arrest in 7 of the 24 families have dominant-negative effects that disrupt microtubule behavior and oocytes meiotic spindle assembly and maturation, causing female infertility.
Journal ArticleDOI
Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest
Yao Xu,Yingli Shi,Jing Fu,Min Yu,Ruizhi Feng,Qing Sang,Bo Liang,Biaobang Chen,Ronggui Qu,Bin Li,Zheng Yan,Xiaoyan Mao,Yanping Kuang,Li Jin,Lin He,Xiaoxi Sun,Lei Wang +16 more
TL;DR: A consanguineous family with a recessive inheritance pattern of female infertility characterized by recurrent early embryonic arrest in cycles of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) is described.
Journal ArticleDOI
Mutations in TUBB8 cause a multiplicity of phenotypes in human oocytes and early embryos
Ruizhi Feng,Zheng Yan,Bin Li,Min Yu,Qing Sang,Guoling Tian,Yao Xu,Biaobang Chen,Ronggui Qu,Zhaogui Sun,Xiaoxi Sun,Li Jin,Lin He,Yanping Kuang,Nicholas J. Cowan,Lei Wang +15 more
TL;DR: The data substantially expand the range of dysfunctional oocyte phenotypes incurred by mutation in TUBB8, underscore the independent nature of human oocyte meiosis and differentiation, extend the class of genetic diseases known as the tubulinopathies and provide new criteria for the qualitative evaluation of meiosis II (MII) oocytes for in vitro fertilization (IVF).
Journal ArticleDOI
MiRNA-320 in the human follicular fluid is associated with embryo quality in vivo and affects mouse embryonic development in vitro
Ruizhi Feng,Qing Sang,Yan Zhu,Wei Fu,Miao Liu,Yan Xu,Huijuan Shi,Yao Xu,Ronggui Qu,Renjie Chai,Ruijin Shao,Li Jin,Lin He,Xiaoxi Sun,Lei Wang +14 more
TL;DR: This study provides the first evidence that miRNAs in human follicular fluid are indicative of and can influence embryo quality.