H
Hubertus M. Verheij
Researcher at Utrecht University
Publications - 133
Citations - 5820
Hubertus M. Verheij is an academic researcher from Utrecht University. The author has contributed to research in topics: Phospholipase A2 & Active site. The author has an hindex of 43, co-authored 133 publications receiving 5740 citations. Previous affiliations of Hubertus M. Verheij include University of Groningen.
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Book ChapterDOI
Structure and function of phospholiphase A2
Journal ArticleDOI
Methylation of Histidine-48 in Pancreatic Phospholipase A2: Role of Histidine and Calcium Ion in the Catalytic Mechanism
Hubertus M. Verheij,J J Volwerk,E. H. J. M. Jansen,W.C. Puyk,Bauke W. Dijkstra,Jan Drenth,G.H. de Haas +6 more
TL;DR: A catalytic mechanism is proposed in which a water molecule which is close to the nitrogen at position 1 of the imidazole ring of the Asp-99-His-48 couple acts as the nucleophile.
Journal ArticleDOI
Structural evidence for dimerization-regulated activation of an integral membrane phospholipase.
H.J. Snijder,I. Ubarretxena-Belandia,I. Ubarretxena-Belandia,Mieke Blaauw,Kor H. Kalk,Hubertus M. Verheij,Maarten R. Egmond,Niek Dekker,Bauke W. Dijkstra +8 more
TL;DR: X-ray structures of monomeric and dimeric OMPLA from E. coli provide a detailed view of activation by dimerization of a membrane protein.
Journal ArticleDOI
X-ray structure of phospholipase A2 complexed with a substrate-derived inhibitor.
Marjolein M.G.M. Thunnissen,Eiso Ab,Kor H. Kalk,Jan Drenth,Bauke W. Dijkstra,Oscar P. Kuipers,R. Dijkman,Gerard H. de Haas,Hubertus M. Verheij +8 more
TL;DR: The structure of a complex between an extracellular phospholipase A2 and a competitively inhibiting substrate analogue is reported, which reveals considerable detail about the interaction and suggests a mechanism for catalysis by this enzyme.
Journal ArticleDOI
Structural basis of the chiral selectivity of Pseudomonas cepacia lipase
Dietmar A. Lang,Maurice L. M. Mannesse,Gerard H. de Haas,Hubertus M. Verheij,Bauke W. Dijkstra +4 more
TL;DR: To investigate the enantioselectivity of Pseudomonas cepacia lipase, inhibition studies were performed with Sc- and Rc-(Rp,Sp)-1,2-dialkylcarbamoylglycero-3-O-p-nitrophenyl alkylphosphonates of differentAlkyl chain lengths.