H
Hudie Wei
Researcher at Central South University
Publications - 8
Citations - 246
Hudie Wei is an academic researcher from Central South University. The author has contributed to research in topics: DNA & Farnesoid X receptor. The author has an hindex of 4, co-authored 8 publications receiving 44 citations.
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Journal ArticleDOI
Targeting MCL-1 in cancer: current status and perspectives.
TL;DR: In this article, the authors discuss the mechanism by which myeloid leukemia 1 regulates cancer cell apoptosis and review the progress related to MCL-1 small molecule inhibitors and their role in cancer therapy.
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Farnesoid X receptor (FXR): Structures and ligands.
TL;DR: In this paper, a review summarizes the structures of the Farnesoid X receptor, especially its ligand binding domain, and the development of small molecules (including agonists and antagonists) targeting FXR.
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Structural basis for DNA recognition by FOXC2.
Xiaojuan Chen,Hudie Wei,Jun Li,Xujun Liang,Shuyan Dai,Longying Jiang,Ming Guo,Lingzhi Qu,Zhuchu Chen,Lin Chen,Yongheng Chen +10 more
TL;DR: In this paper, two crystal structures of the DNA-binding domain (DBD) of human FOXC2 protein, in complex with different DNA sites, were determined and a model of DNA binding for the FOXC proteins was provided.
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Mechanism of forkhead transcription factors binding to a novel palindromic DNA site.
Jun Li,Shuyan Dai,Xiaojuan Chen,Xujun Liang,Lingzhi Qu,Longying Jiang,Ming Guo,Zhan Zhou,Hudie Wei,Huajun Zhang,Zhuchu Chen,Lin Chen,Yongheng Chen +12 more
TL;DR: In this article, FoxO1 recognizes a palindromic DNA element DIV2, and mediates transcriptional regulation by binding a canonical consensus DNA motif, RYAAAYA (R = A/G, Y = C/T).
Journal ArticleDOI
Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
Hudie Wei,Lingzhi Qu,Shuyan Dai,Yun Li,Haolan Wang,Yilu Feng,Xiaojuan Chen,Longying Jiang,Ming Guo,Jun Li,Zhuchu Chen,Lin Chen,Ye Zhang,Yongheng Chen +13 more
TL;DR: The structure of human tumor suppressor p53 in complex with the anti-apoptotic protein BCL-xL reveals the basis of the p53/BCL-xl interaction and provides insight into the mechanisms of p53-mediated mitochondrial apoptosis.