Hugh Morgan

TL;DR: It is demonstrated here that this maternal epigenetic effect is not the result of a maternally contributed environment, and results from incomplete erasure of an epigenetic modification when a silenced Avy allele is passed through the female germ line, with consequent inheritance of the epigenetic modified.

TL;DR: It is found that the methylation state of AxinFu in mature sperm reflects the methylated state of the allele in the somatic tissue of the animal, suggesting that it does not undergo epigenetic reprogramming during gametogenesis, and it is shown that epigenetic inheritance is influenced by strain background.

TL;DR: Evidence suggests that epigenetic modifications, which in the past were thought to be cleared and reset on passage through the germline, may sometimes be inherited to the next generation, and may well turn out to be the explanation for some diseases which appear to be sporadic or show only weak genetic linkage.

TL;DR: The germline inheritance of transcriptional silencing in mice and reversion to activity after as many as three generations in the silent state supports the notion that silent genetic information in mammals can be inherited and later reactivated and implies a mode of phenotypic inheritance that is less stable than Mendelian inheritance.

TL;DR: The present findings suggest that distractibility and psychomotor agitation may represent the core of mixed states, as they are more common in patients with mixed depression and bipolar spectrum disorder than patients diagnosed with unipolar Depression and bipolar I disorder.