H
Hugh Rosen
Researcher at Scripps Research Institute
Publications - 233
Citations - 20491
Hugh Rosen is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 70, co-authored 232 publications receiving 19168 citations. Previous affiliations of Hugh Rosen include Free University of Berlin & National Institutes of Health.
Papers
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Journal ArticleDOI
The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.
Jeffrey J. Hale,George A. Doherty,Leslie Toth,Zhen Li,Sander G. Mills,Richard Hajdu,Carol Ann Keohane,Mark Rosenbach,James A. Milligan,Gan-Ju Shei,Gary Chrebet,James D. Bergstrom,Deborah Card,Hugh Rosen,Suzanne M. Mandala +14 more
TL;DR: 3-(N-Alkyl)aminopropylphosphonic acids are potent agonists of four of the five known sphingosine-1-phosphate (S1P) receptor subtypes.
Journal ArticleDOI
Pharmacokinetics of L-749,345, a long-acting carbapenem antibiotic, in primates.
TL;DR: The chimpanzee pharmacokinetics was predictive of human results and indicated a compound that was superior to IPM and approached CTX in its ability to persist in the circulation and the extended half-life at elimination phase of L-749,345 allows consideration of single daily dosing.
Journal Article
Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice.
TL;DR: The contention that CD11b molecules expressed in the myelomonocytic cells play a critical role in this naturally occurring inflammatory disease, the viable moth-eaten (mev) mutant mouse, is supported.
Journal ArticleDOI
S1P1-selective agonist SEW2871 exacerbates reperfusion arrhythmias.
TL;DR: The first demonstration of the critical role of the S1P1 receptor in I/R injury is demonstrated, leading to irreversible reperfusion tachyarrhythmias in 60% of the hearts.
Peer ReviewDOI
Author response: Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
Lars Plate,Christina B. Cooley,John J. Chen,Ryan J Paxman,Ciara M Gallagher,Franck Madoux,Franck Madoux,Joseph C. Genereux,Wesley Dobbs,Dan Garza,Timothy P. Spicer,Timothy P. Spicer,Louis Scampavia,Louis Scampavia,Steven J. Brown,Hugh Rosen,Evan T. Powers,Peter Walter,Peter Hodder,Peter Hodder,R. Luke Wiseman,Jeffery W. Kelly +21 more