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Dan Garza
Researcher at Novartis
Publications - 30
Citations - 3635
Dan Garza is an academic researcher from Novartis. The author has contributed to research in topics: Proteostasis & Protein folding. The author has an hindex of 17, co-authored 27 publications receiving 3284 citations.
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Journal ArticleDOI
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
Udai Bhan Pandey,Zhiping Nie,Yakup Batlevi,Brett A. McCray,Gillian P. Ritson,Natalia B. Nedelsky,Stephanie L. Schwartz,Nicholas A. Diprospero,Melanie Knight,Oren Schuldiner,Ranjani Padmanabhan,Marc Hild,Deborah L. Berry,Dan Garza,Charlotte Hubbert,Tso-Pang Yao,Eric H. Baehrecke,J. Paul Taylor +17 more
TL;DR: It is shown that autophagy acts as a compensatory degradation system when the UPS is impaired in Drosophila melanogaster, and that histone deacetylase 6 (HDAC6), a microtubule-associated de acetylase that interacts with polyubiquitinated proteins, is an essential mechanistic link in this compensatory interaction.
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A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease.
Marc Brehme,Cindy Voisine,Thomas Rolland,Shinichiro Wachi,James Soper,Yitan Zhu,Kai Orton,Adriana Villella,Dan Garza,Marc Vidal,Hui Ge,Richard I. Morimoto +11 more
TL;DR: A critical chaperome subnetwork that functions in aging and disease is identified using function, localization, interactome, and expression data sets to identify repression and induction clusters in human brain aging.
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Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells
Vadim Iourgenko,Wenjun Zhang,Craig Mickanin,Ira Daly,Can Jiang,Jonathan M. Hexham,Anthony P. Orth,Loren Miraglia,Jodi Meltzer,Dan Garza,Gung-Wei Chirn,Elizabeth McWhinnie,Dalia Cohen,Joanne Skelton,Robert D. Terry,Yang Yu,Dale L. Bodian,Frank Buxton,Jian Zhu,Chuanzheng Song,Mark Labow +20 more
TL;DR: TORCs represent a family of highly conserved CREB coactivators that may control the potency and specificity of CRE-mediated responses and represent an unbiased method for systematically determining gene function in mammalian cells.
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Activation of cAMP Response Element-Mediated Gene Expression by Regulated Nuclear Transport of TORC Proteins
Mark Bittinger,Elizabeth McWhinnie,Jodi Meltzer,Vadim Iourgenko,Brian Jude Latario,Xiulin Liu,Chein Hwa Chen,Chuanzheng Song,Dan Garza,Mark Labow +9 more
TL;DR: TORC function was shown to be essential for CRE-mediated gene expression induced by cAMP, calcium, or GPCR activation, and nuclear transport of TORC1 was sufficient to activate CRE-dependent transcription.
Journal ArticleDOI
Small-molecule proteostasis regulators for protein conformational diseases
Barbara Calamini,Maria Catarina Silva,Franck Madoux,Darren M. Hutt,Shilpi Khanna,Monica A. Chalfant,S. Adrian Saldanha,Peter Hodder,Bradley D. Tait,Dan Garza,William E. Balch,Richard I. Morimoto +11 more
TL;DR: It is suggested that modulation of the proteostasis network by PRs represents a promising therapeutic approach for the treatment of a variety of protein conformational diseases.