H
Hugo L. David
Researcher at Centers for Disease Control and Prevention
Publications - 15
Citations - 880
Hugo L. David is an academic researcher from Centers for Disease Control and Prevention. The author has contributed to research in topics: Mycobacterium tuberculosis & Mycobacterium. The author has an hindex of 12, co-authored 15 publications receiving 842 citations. Previous affiliations of Hugo L. David include United States Department of Veterans Affairs & Emory University.
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Probability distribution of drug-resistant mutants in unselected populations of Mycobacterium tuberculosis.
TL;DR: The fluctuation test shows that Mycobacterium tuberculosis mutates to resistance to isoniazid, streptomycin, ethambutol and rifampin spontaneously and at random.
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Effect of Isoniazid on the In Vivo Mycolic Acid Synthesis, Cell Growth, and Viability of Mycobacterium tuberculosis
TL;DR: The results strongly suggest that the inhibition of the synthesis of the mycolic acids is closely associated with the primary mechanism of action of isoniazid on the tubercle bacilli.
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Effect of temperature on the rate of the transparent to opaque colony type transition in Mycobacterium avium.
Charles L. Woodley,Hugo L. David +1 more
TL;DR: Judged from the data, the high rate of the transparent to opaque variation was not caused either by mutator effects or by the occurrence of extrachromosomal genes in these bacteria, but could have been due to selective mechanisms still incompletely understood.
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Ultraviolet light inactivation and photoreactivation in the mycobacteria.
TL;DR: The kinetics of inactivation of mycobacteria by ultraviolet light were investigated and Mycobacterium tuberculosis and M. marinum were shown to be capable of photo-reactivation.
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Resistance to D-cycloserine in the tubercle bacilli: mutation rate and transport of alanine in parental cells and drug-resistant mutants
TL;DR: The data were consistent with the conclusion that resistance to d-cycloserine in the tubercle bacilli is primarily due to mutations in the gene(s) controlling the enzyme d-alanyl-d-alanine synthetase.