Hugues Legendre

TL;DR: The current study analyzed the prognostic values contributed by galectin‐1, galECTin‐3, galect in‐4, and galectIn‐4 in cases of colon carcinoma to find out whether these values are related to prognostic value or not.

TL;DR: Their expression significantly increased with the degree of dysplasia, suggesting that gal‐1 and gal‐3 and their binding sites are related to malignant progression, while gal‐8 has been associated with suppressor activity.

TL;DR: The present study deals with the quantitative determination of immunohistochemical expression of galectin-8 in normal, benign, and malignant human colon tissue samples and in four human colon cancer models maintained both in vitro as permanent cell lines and in vivo as nude mice xenografts.

TL;DR: MIF and galectin-3 expression levels in colorectal tumors are related to their levels of biological aggressiveness and could be used to identify patients at risk, for whom more aggressive adjuvant therapy seems to be indicated.

TL;DR: Palliative surgery can, in a certain number of cases, improve the quality of life of patients, but it has not been possible for us to demonstrate prognostic factors which would allow the selection of patients who could benefit the most from such surgery.