H
Hui Wen Chiu
Researcher at Taipei Medical University
Publications - 46
Citations - 1413
Hui Wen Chiu is an academic researcher from Taipei Medical University. The author has contributed to research in topics: Autophagy & Programmed cell death. The author has an hindex of 18, co-authored 36 publications receiving 1080 citations. Previous affiliations of Hui Wen Chiu include National Cheng Kung University.
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Journal ArticleDOI
Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts.
Yu Hsuan Lee,Fong Yu Cheng,Hui Wen Chiu,Jui Chen Tsai,Chun Yong Fang,Chun Wan Chen,Ying Jan Wang +6 more
TL;DR: Interestingly, AgNPs induced morphological and biochemical markers of autophagy in NIH 3T3 cells and induced autophagosome formation, as evidenced by transmission electron microscopic analysis, the formation of microtubule-associated protein-1 light chain-3 (LC3) puncta and the expression of LC3-II protein.
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Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress
Hui Wen Chiu,Hui Wen Chiu,Tian Xia,Yu Hsuan Lee,Chun Wan Chen,Jui Chen Tsai,Ying Jan Wang,Ying Jan Wang,Ying Jan Wang +8 more
TL;DR: An important role of autophagy is suggested in cationic NP-induced cell death and mechanistic insights into the inhibition of the toxicity and safe material design are provided.
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Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K/Akt and ERK1/2 signaling pathways.
TL;DR: The enhanced cytotoxic effect of IR combined with ATO was through induction of more autophagy in U118-MG cells, which were characterized by the presence of acidic vascular organelle formation, determined by electron microscopic observation and immunoblotting of LC3.
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Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis.
TL;DR: Investigation of the anticancer effects of ionizing radiation (IR) combined with arsenic trioxide (ATO) in human fibrosarcoma cells in vitro and in xenograft tumors in SCID mice in vivo suggests that a combination of IR and ATO could be a new potential therapeutic strategy for the treatment of fibrosARcoma.
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Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Enhances Radiosensitivity and Suppresses Lung Metastasis in Breast Cancer In Vitro and In Vivo
Hui Wen Chiu,Ya Ling Yeh,Yi Ching Wang,Wei Jan Huang,Yi An Chen,Yi Shiou Chiou,Yi Shiou Chiou,Sheng Yow Ho,Pinpin Lin,Ying Jan Wang +9 more
TL;DR: It is found that IR combined with SAHA showed increased therapeutic efficacy when compared with either treatment alone in MCF-7, MDA-MB-231 and 4T1 cells and SAHA not only enhances radiosensitivity but also suppresses lung metastasis in breast cancer.